AUTOIMMUNE HEMOLYTIC ANEMIA Flashcards
1
Q
this is termed warm or cold depending on type of antibody involved and the temperature at which it agglutinates?
A
autoimmune hemolytic anemia
2
Q
autoantibody found in warm AIHA?
A
IgG
3
Q
tested with? for cold, what are the positive results?
A
direct Coombs test
for cold, positive if an anti-C3 Coombs reagent is used inst4ead of anti-IgG
4
Q
autoantibody found in cold AIHA?
A
IgM
5
Q
what are the two types cold AIHA?
primary
secondary
A
primary: cold agglutination disease
secondary: infection(mycoplasma, mononucleosis, malignancy)
6
Q
this is also another form in addition to warm and cold AIHA? autoantibodies generated?
where do they bind?
A
drug induced AIHA
IgG,IgM
RBC membrane, protein, autoantibody formation
