CNS INJURY BASICS HIGH YIELD Flashcards
neurons are topographically organized into _____?
nuclei, ganglia, and columns
neuronal injury patterns?
evident acute injury
marked H/E staining in hypoxic injuries
coagulative necrosis
apoptosis
patterns of neuronal injury?
shrunken cell bodies due to acute hypoxic ischemic injury
axonal spheroid bulbous swellings
swelling of the cell body and peripheral dispersal o the Nissl substance due to axonal injury
this is the most important indicator of CNS injury?
what is involved?
Gliosis
shrinkage of astrocytic cytoplasm
tightly interwoven cellular processes
Rosenthal fibers
most common cell in whiter matter
smaller than astrocytes
oligodendrocytes
targeted in infectious agents (CMV)
ependymal cells
derived from bone marrow
activated by injury, infection, or trauma
take on appearance of activated macrophages
microglial cells
features unique to the brain?
brain function is localized w/in the nervous system
brain has anatomy that both protects the brain and renders it more vulnerable to insult
similar symptoms/clincial findings can be produced through different pathlogical mechanism
certain diseases are unique to neuropathology
