LEUKEMIA Flashcards
abnormally low WBC, decreased number of neutrophils
observed in: advanced HIV infection glucocorticoids acute viral infections congenital immunodeficiency
leukopenia
reduced numbers of neutrophils
counts less than 1000 are worrisome, less than 500 indicate infection
occurs with:
reduced or ineffective production
accelerated removal from circulation
neutropenia
malignant neoplasms of hematopoietic stem cell characterized by diffuse replacement of bone marrow by neoplastic cells; leukemic cells spill into blood where they can infiltrate tissues throughout body
based on: clinical features morphology immunophenotype genotype
leukemia
what are the types of acute leukemia?
acute lymphoblastic leukemia
acute myelogenous leukemia
what are the types of chronic lymphocytic disorders?
chronic lymphocytic leukemia/small cell lymphoma hairy cell leukemia chronic myelogenous leukemia polycythemia vera primary myelofibrosis essential thrombocytosis
how is leukemia classified?
lymphoid
myeloid
classification for myeloid?
FAB, French American British
classification for lymphoid neoplasms?
REAL system, revised Euro-american classification of lymphoid neoplasms
this classification scheme for leukemia is the most current divided into 5 broad categories which includes rare entities not found in the REAL system
this encompasses all lymphoid neoplasms
based on: morphology cell of origin clinical features genotypes
WHO system
what are the 5 categories of The Who system?
precursor B cell neoplasm peripheral B cell neoplasm precursor T cell neoplasm peripheral T cell and NK cell neoplasm Hodgkin lymphoma
