CELL DEATH HIGH YIELD Flashcards
what are the effects of necrosis in cell death?
loss of membrane integrity and dissolution of cell
leakage of cellular contents
nuclear changes
leakage of cellular contents indicates?
inflammation
examples of nuclear changes?
pyknosis
karyolysis
karyorrhexis
name the types of necrosis?
coagulative
liquefactive
caseous
fat
when is apoptosis necessary, describe it?
when cells are no longer needed, maintain cell populations
when does apoptosis occur?
embryogenesis hormone dependent cell deletion deletion of auto reactive t cells injury
how is apoptosis induced?
by a tightly regulated intracellular program
T/F, cellular membrane remains intact?
T
what is the morphology of the cell under apoptosis?
cell shrinkage
chromatin condensation
formation of cytoplasmic blebs
phagocytosis of apoptotic cellls
what is the specific molecular mechanism for apoptosis?
activation of caspases
what 2 distinctive pathways cause the activation of caspases?
mitochondrial (intrinsic) pathway
death receptor (extrinsic) pathway
what are the events that happen in apoptosis during pathologic conditions?
injurious stimuli
certain viral diseases
pathologic atrophy following ductal obstruction: pancreas, parotid gland, kidney
cell death in tumors
what are the intracellular accumulations?
abnormal metabolism
protein mutation
lack of enzyme
ingestion of indigestible materials
can you tell what protein is involved when hyaline changes occur?
example?
produced by a variety of alterations
reabsorption droplets from the renal tubules
what are the examples of pathologic calcification?
metastatic calcification
dystrophic calcification
