FIRST AID IMPORTANT CYTOKINES Flashcards
also called osteoclast activating factor
causes fever, acute inflammation
activates endothelium to express adhesion molecules
induces chemokine secretion to recruit WBCs
IL-1
causes fever and stimulates production of acute phase proteins
IL-6
major chemotactic factor for neutrophils
IL-8
induces differentiation of T cells into Th1 cells
activates NK cells
IL-12
mediates septic shock
activates endothelium ]
causes WBC recruitment, vascular leak
causes cachexia in malignancy
TNF-alpha
stimulates growth of helper, cytotoxic and regulatory T cells and NK cells
IL-2
supports growth and differentiation of bone marrow stem cells
functions like GM-CSF
IL-3
secreted by NK cells and T cells in response to IL-12 form macrophages;
stimulates macrophages to kill phagocytosed pathogens
inhibits differentiation of Th2 cells
activates NK cells to kill virus infected cells. Increases MHC expression and antigen presentation by all cells
INF gamma
induces differentiation of T cells into Th2 cells
promotes growth of B cells.
Enhances class to switching IgI and IgG
lL-4
promotes growth and differentiation of B cells
enhances class switching to IgA
stimulates growth and differentiation of eosinophils
IL-5
attenuates inflammatory response
decreases expression of MHC class II and Th1 cytokines
inhibits activated macrophages and dendritic cells
also secreted by reg T cells
TGF-B and IL-10 both attenuate the immune response
IL-10
IL-1 IL-6 IL-8 IL-12 TNF-alpha
secreted by macrophages
IL-2
IL-3
secreted by all T cells
interferon gamma
secreted by Th1 cells
IL-4
IL-5
IL-10
secreted by Th2 cells
