Drug rxns Flashcards Preview

USMLE Step 1 Random Facts > Drug rxns > Flashcards

Flashcards in Drug rxns Deck (45):
1

coronary vasospasm

cocaine
sumatriptan
ergot alkaloids

2

cutaneous flushing

vancomycin
adenosine
niacin
CCB

"VANC"

3

dilated cardiomyopathy

doxorubicin (adriamycin)
daunorubicin

4

torsades de pointes

class III (sotalol) and class IA (quinidine) antiarrhythmics

5

agranulocytosis

clozapine
carbamazepine
cochicine
PTU
methimazole
dapsone

"Agranulocytosis Could Certainly Cause Pretty Major Damage"

6

Aplastic anemia

chloramphenicol
benzene
NSAIDs
PTU
methimazole

7

direct Coombs-positive hemolytic anemia

methyldopa
penicillin

8

gray baby synd

chloramphenicol

9

hemolysis in G6PD-deficient pts

isoniazid
sulfonamides
primaquine
aspirin
ibuprofen
nitrofuratoin

"hemolysis IS PAIN"

10

megaloblastic anemia

phenytoin
methotrexate
sulfa drugs

"having a BLAST w/ PMS"

11

thrombotic complications

OCPs (eg. estrogen)

12

cough

ACE inhibitors

13

pulmonary fibrosis

bleomycin
amiodarone
busulfan

"it's hard to BLAB when you have pulm fibrosis"

14

acute cholestatic hepatitis, jaundice

erythromycin

15

focal to massive hepatic necrosis

halothane
amanita phalloides
valproic acid
acetominophen

"liver HAVAc"

16

hepatitis

INH

17

pseudomembranous colitis

clindamycin
ampicillin

18

adrenocortical insuff

glucocorticoid withdrawal (HPA suppression)

19

gynecomastia

spironolactone
digitalis
cimetidine
chronic alcohol use
estrogens
ketoconazole

"Some Drugs Create Awkward Knockers"

20

hot flashes

tamoxifen
clomiphene

21

hyperglycemia

niacin
tacrolimus
protease inhibitors
HCTZ
corticosteroids

22

hypothyroidism

lithium
amiodarone
sulfonamides

23

fat redistribution

glucocorticoids
protease inhibitors

24

gingival hyperplasia

phenytoin
verapamil

25

gout

furosemide
thiazides
niacin
cyclosporine

26

myopathies

Fibrates
Niacin
Colchicine
Hydroxychloroquine
IFN-alpha
Penicillamine
Statins
Glucocorticoids

"Fish N CHIPS Give you myopathies"

statins + fibrates greatly increases risk

27

osteoporosis

corticosteroids
heparin

28

photosensitivity

Sulfonamides
Amiodarone
Tetracycline

"SAT for a photo"

29

Rash (Stevens-Johnson synd)

Pencillin
Ethosuxamide
Carbamazepine
Sulfa drugs
Lamotrigine
Allopurinol
Phenytoin
Phenobarbital

"bad rash after a PEC SLAPP"

3 main categories that cause it: penicillin, sulfa drugs, seizure drugs

30

SLE-like synd

Hydralazine
INH
Procainamide
Phenytoin

"it's not HIPP to have lupus"

31

Teeth (kids)

tetracyclines

32

tendonitis, tendon rupture, cartilage damage

fluoroquinolones

33

diabetes insipidus

Lithium
demeclocycline

34

Fanconi's synd (disease of the proximal renal tubules of the kidney in which glucose, amino acids, uric acid, phosphate and bicarbonate are passed into the urine instead of being reabsorbed)

expired tetracycline

35

hemorrhagic cystitis

cyclophosphamide
ifosfamide

**prevent by co-admin w/ mesna

36

interstitial nephritis

methicillin
NSAIDs
furosemide

37

SIADH

cabamazepine
cyclophosphamide

38

cinchonism (temporary deafness, ringing in the ears, headache, dizziness, and rash)

Quinidine
quinine

39

parkinson-like synd

antipsychotics
reserpine
metoclopramide

40

Seizures

Isoniazid
Bupropion
Imipenem/cilastatin
Tramadol
Enflurane
Metoclopramide

"with seizures, I BITE My tongue"

41

Tardive dyskinesia

antipsychotics

42

antimuscarinic

atropine
TCAs
H1 blockers
neuroleptics

43

disulfiram-like rxn

metronidazole
certain cephalosporins (cefoperazone and cefotetan)
procarbazine
1st gen sulfonylureas
griseofulvin

44

Nephrotoxicity/otoxicity

aminoglycosides
vancomycin
loop diuretics
cisplatin

45

blurry yellow vision

digoxin