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Flashcards in Teratogens Deck (20):
1

ACE inhibitors

renal damage

2

alkylating agents

absence of digits, multiple anomalies

3

aminoglycosides

CN VIII toxicity

"A MEAN GUY hit the baby in the ear"

4

carbamazepine

neural tube defects
craniofacial defects
fingernail hypoplasia
developmental delay
IUGR

5

diethylstilbestrol (DES)

vaginal clear cell adenocarcinoma
congenital Mullerian anomalies

6

folate antagonists

neural tube defects

7

lithium

ebstein's anomaly (atrialized right heart - downward displacement of tricuspid valve)

8

phenytoin

fetal hydantoin syndrome: microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, mental retardation

9

tetracyclines

discolored teeth

10

thalidomide

limb defects ("flipper" limbs)

"Limb defects with 'tha-LIMB-domide'

11

valproate

inhibition of maternal folate absorption --> NEURAL TUBE DEFECTS

12

warfarin

bone deformities
fetal hemorrhage
abortion
ophthalmologic abnormalities

"Do not wage WARFARe on the baby; keep it HEPpy w/ HEParin (does not cross placenta)"

13

alcohol

leading cause of birth defects and mental retardation
fetal alcohol synd

14

cocaine

abnormal fetal dev't and fetal addiction
placental abruption (vasoconstriction --> insuff blood flow to fetus --> spontaneous abortion, IUGR, prematurity)

15

smoking (nicotine, CO)

preterm labor
placental problems
IUGR
ADHD

16

iodide (lack or excess)

congenital goiter or hypothyroidism (cretinism)

17

maternal diabetes

caudal regression synd - born w/ agenesis of sacrum + occasionally lumbar spine (anal atresia to sirenomelia)
congenital heart defects (VSD, transposition of great vessels)
neural tube defects
renal agenesis

18

vit A (excess)

extremely high risk for spontaneous abortions and birth defects (cleft palate, cardiac abnormalities, craniofacial abnorm, post fossa CNS defects, abnorm of great vessels)

19

x-rays

microcephaly
Mental retardation

20

fluoroquinolones

cartilage damage

"fluoroquinolones hurt the bones"