Rate-limiting enzymes Flashcards Preview

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Flashcards in Rate-limiting enzymes Deck (13):
1

glycolysis

PFK-1
stim by: AMP, F-2,6-BP
inhib by: ATP, citrate

2

gluconeogenesis

F-1,6-bisphosphatase
stim by: ATP
inhib by: AMP, F-2,6-BP

3

TCA cycle

isocitrate dehydrogenase
stim by: ADP
inhib by: ATP, NADH

4

glycogen synthesis

glycogen synthase
stim by: insulin, glucose
inhib by: glucagon, epinephrine

5

glycogenolysis

glycogen phosphorylase
stim by: AMP, glucagon, epinephrine
inhib by: ATP, insulin

6

HMP shunt

G6PD
stim by: NADP
inhib by: NADPH

7

de novo pyrimidine synthesis

CPS-II

8

de novo purine synthesis

glutamine-PRPP amidotransferase
inhib by: AMP, IMP, GMP

9

urea cycle

CPS-I
stim by: N-acetylglutamate

10

FA synthesis

acetyl-CoA carboxylase
stim by: insulin, citrate
inhib by: glucagon, palmitoyl-CoA

11

FA oxidation

Carnitine acyltransferase I
inhib by: malonyl-CoA

12

ketogenesis

HMG-CoA synthase

13

cholesterol synthesis

HMG-CoA reductase
stim by: insulin, thyroxine
inhib by: glucagon, cholesterol