Flashcards in MSK Deck (55):
C7 root lesion?
cervical disk lesion
axillary n. lesion?
1) fracture of SURGICAL neck
2) dislocation of humerus
3) intramuscular injections
lower trunk of brachial plexus lesion?
compressed by cervical rib
Pancoast tumor of lung
leads to Klumpke's palsy
radial n. in spiral groove lesion?
MIDSHAFT fracture of humerus
radial n. lesion?
compression in AXILLA by crutches, back of chair, etc.
median n. lesion?
compressed by SUPRACONDYLAR fracture of humerus
pronator teres synd
compressed in CARPAL TUNNEL SYND
radial n. (deep branch) lesion?
stretched by SUBLUXATION of radius ("nursemaid's elbow")
ulnar n. lesion?
fracture of MEDIAL EPICONDYLE of humerus
fracture of HOOK OF HAMATE (Guyon's canal)
anterior interosseous n. lesion?
compressed in deep forearm
axillary n. levels, motor, sensory?
m- deltoid (arm ABduction @ shoulder)
s - over deltoid muscle and lateral upper arm
radial n. levels, motor, sensory?
m- brachioradialis, Extensors of wrist/fingers, Supinator, Triceps ("BEST extensors")
s- posterior arm (from post. cutaneous n. of arm), dorsal hand (from superficial branch of radial n.), THUMB
median n. levels, motor, sensory?
m - opposition of thumb, lateral finger flexion, wrist flexion, pronation
s - dorsal/palmar aspects of lateral 3 1/2 fingers, thenar eminence
ulnar n. levels, motor, sensory?
m - medial finger flexion, wrist flexion, intrinsic hand muscles
s - medial 1 1/2 fingers, hypothenar eminence
musculocutaneous n. levels, motor, sensory?
m - biceps, brachialis, coracobrachialis; flexion of arm @ elbow
s - lateral forearm
axillary n. injury sign?
radial n. injury sign?
median n. injury sign?
ulnar n. injury sign?
RADIAL DEVIATION of wrist on wrist flexion
tight junctions (zonula occludens)
prevent paracellular movement of solutes
composed of claudins, occludins
adherens junction (zonula adherans)
"belt" connecting actin cytoskeletons of adjacent cells w/ cadherins
loss of E-cadherin --> promotes matastasis
desmosome (macula adherens)
support via keratin
connect epith cells together
connexons - permit electrical/chemical comm b/w cells
**abundant in MYOCYTES!
connect keratin in basal cells to underlying BM
membrane proteins that maintain integrity of BM by binding to laminin in BM
abducts 10-15 degrees
>30 to 90 = deltoid
>90 = trapezius, serratus anterior
teres minor m.
adduction, lateral rotation
adduction, medial rotation
osteitis fibrosa cystica =
brown tumor of hyperparathyroidism
increased Ca, PTH, ALP
McCune Albright synd
multiple unilat bone lesions (fibrous dysplasia)
impt RF for osteoarthritis
In RA, inflamm causes arginine residues in proteins like vimentin to convert into?
Sjogren's increases risk of
Sjogren's has Ab against what
ankylosing spondylitis features?
ankylosis (stiff spine due to fusion of joints) - improves w/ exercise
polymyositis inflamm =
endomysial inflamm w/ CD8 T-cells
dermatomyositis inflamm =
perimysial (perifascicular) inflamm + atrophy w/ CD4 T-cells
flaking off of STRATUM CORNEUM
retention of nuclei in stratum corneum
increased thickness of stratum corneum
seen in psoriasis, actinic keratosis
hyperkeratosis w/ retention of nuclei in stratum corneum
seen in psoriasis, actinic keratosis
separation of epidermal cells
seen in pemphigus vulgaris
epidermal hyperplasia (increased stratum SPINOSUM)
seen in acanthosis nigracans
inflamm of skin
seen in atopic dermatitis
excessive granulation in stratum granulosum
seen in lichen planus
epidermal accum of edematous fluid in intercellular spaces
seen in eczematous/contact dermatitis
changes seen in psoriasis
increased stratum spinosum
decreased stratum granulosum
sudden onset of multiple seborrheic keratoses
indicates underlying malig, usually colon cancer
dermatitis herpetiformis features
formation of MICROABSCESSES w/ fibrin + neutrophils @ dermal papillae tips
Ab against gliadin cross-react w/ RETICULIN (found in anchoring fibrils of epidermal BM)
erythema multiforme commonly ass w/ what infection
lichen planus commonly ass w/
pain out of proportion to findings seen in what 2 conditions
SSSS vs. toxic epidermal necrolysis
SSSS - sloughing of stratum granulosum ONLY
TEN - destroys dermal-epidermal junction
cup-shaped tumor w/ keratin debris in center
grows rapidly, may regress spontaneously