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Flashcards in MSK Deck (55):
1

C7 root lesion?

cervical disk lesion

2

axillary n. lesion?

1) fracture of SURGICAL neck
2) dislocation of humerus
3) intramuscular injections

3

lower trunk of brachial plexus lesion?

compressed by cervical rib
Pancoast tumor of lung

leads to Klumpke's palsy

4

radial n. in spiral groove lesion?

MIDSHAFT fracture of humerus

5

radial n. lesion?

compression in AXILLA by crutches, back of chair, etc.

6

median n. lesion?

compressed by SUPRACONDYLAR fracture of humerus
pronator teres synd
compressed in CARPAL TUNNEL SYND
dislocated lunate

7

radial n. (deep branch) lesion?

stretched by SUBLUXATION of radius ("nursemaid's elbow")

8

ulnar n. lesion?

fracture of MEDIAL EPICONDYLE of humerus
fracture of HOOK OF HAMATE (Guyon's canal)

9

anterior interosseous n. lesion?

compressed in deep forearm

10

axillary n. levels, motor, sensory?

C5-C6
m- deltoid (arm ABduction @ shoulder)
s - over deltoid muscle and lateral upper arm

11

radial n. levels, motor, sensory?

C5-T1
m- brachioradialis, Extensors of wrist/fingers, Supinator, Triceps ("BEST extensors")
s- posterior arm (from post. cutaneous n. of arm), dorsal hand (from superficial branch of radial n.), THUMB

12

median n. levels, motor, sensory?

C5-C8, T1
m - opposition of thumb, lateral finger flexion, wrist flexion, pronation
s - dorsal/palmar aspects of lateral 3 1/2 fingers, thenar eminence

13

ulnar n. levels, motor, sensory?

C8, T1
m - medial finger flexion, wrist flexion, intrinsic hand muscles
s - medial 1 1/2 fingers, hypothenar eminence

14

musculocutaneous n. levels, motor, sensory?

C5-C7
m - biceps, brachialis, coracobrachialis; flexion of arm @ elbow
s - lateral forearm

15

axillary n. injury sign?

atrophied deltoid

16

radial n. injury sign?

wrist drop

17

median n. injury sign?

"ape hand"
"Pope's blessing"

18

ulnar n. injury sign?

RADIAL DEVIATION of wrist on wrist flexion

19

tight junctions (zonula occludens)

prevent paracellular movement of solutes
composed of claudins, occludins
**in brain

20

adherens junction (zonula adherans)

"belt" connecting actin cytoskeletons of adjacent cells w/ cadherins
loss of E-cadherin --> promotes matastasis

21

desmosome (macula adherens)

support via keratin
connect epith cells together

22

gap junction

connexons - permit electrical/chemical comm b/w cells
**abundant in MYOCYTES!

23

hemidesmosome

connect keratin in basal cells to underlying BM
contain integrins

24

integrins

membrane proteins that maintain integrity of BM by binding to laminin in BM

25

supraspinatus m.

abducts 10-15 degrees
>30 to 90 = deltoid
>90 = trapezius, serratus anterior

26

infraspinatus m.

lateral rotation

27

teres minor m.

adduction, lateral rotation

28

subscapularis m.

adduction, medial rotation

29

osteitis fibrosa cystica =

brown tumor of hyperparathyroidism
increased Ca, PTH, ALP
decreased phosphate

30

McCune Albright synd

multiple unilat bone lesions (fibrous dysplasia)
precocious puberty
cafe-au-lait spots

31

impt RF for osteoarthritis

age

32

In RA, inflamm causes arginine residues in proteins like vimentin to convert into?

citrulline

33

Sjogren's increases risk of

B-cell lymphoma

34

Sjogren's has Ab against what

ribonucleoprotein antigens

35

ankylosing spondylitis features?

ankylosis (stiff spine due to fusion of joints) - improves w/ exercise
uveitis
aortic regurg

36

polymyositis inflamm =

endomysial inflamm w/ CD8 T-cells
increased aldolase

37

dermatomyositis inflamm =

perimysial (perifascicular) inflamm + atrophy w/ CD4 T-cells

38

scale =

flaking off of STRATUM CORNEUM

39

hyperparakeratosis

retention of nuclei in stratum corneum

40

hyperkeratosis

increased thickness of stratum corneum
seen in psoriasis, actinic keratosis

41

parakeratosis

hyperkeratosis w/ retention of nuclei in stratum corneum
seen in psoriasis, actinic keratosis

42

acantholysis

separation of epidermal cells
seen in pemphigus vulgaris

43

acanthosis

epidermal hyperplasia (increased stratum SPINOSUM)
seen in acanthosis nigracans

44

dermatitis

inflamm of skin
seen in atopic dermatitis

45

hypergranulosis

excessive granulation in stratum granulosum
seen in lichen planus

46

spongiosis

epidermal accum of edematous fluid in intercellular spaces
seen in eczematous/contact dermatitis

47

changes seen in psoriasis

increased stratum spinosum
decreased stratum granulosum

48

Lesler-Trelat sign

sudden onset of multiple seborrheic keratoses
indicates underlying malig, usually colon cancer

49

dermatitis herpetiformis features

formation of MICROABSCESSES w/ fibrin + neutrophils @ dermal papillae tips
Ab against gliadin cross-react w/ RETICULIN (found in anchoring fibrils of epidermal BM)

50

erythema multiforme commonly ass w/ what infection

HSV

51

lichen planus commonly ass w/

HCV

52

pain out of proportion to findings seen in what 2 conditions

necrotizing fasciitis
ischemic colitis

53

SSSS vs. toxic epidermal necrolysis

SSSS - sloughing of stratum granulosum ONLY
TEN - destroys dermal-epidermal junction

54

cup-shaped tumor w/ keratin debris in center

keratoacanthoma
grows rapidly, may regress spontaneously

55

salicylate poisoning (early/late)

early - resp alkalosis bc stim of resp center
late - increased anion gap metab acidosis