Tumor Markers Flashcards Preview

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Flashcards in Tumor Markers Deck (37):
1

abl

O; CML
GP = tyrosine kinase

2

c-myc

O; Burkitt's lymphoma
GP = transcription factor

3

bcl-2

O; follicular and undifferentiated lymphomas (inhib apoptosis)
GP = anti-apoptotic molec

4

HER2/neu (c-erbB2)

O; breast, ovarian, gastric carcinomas
GP = tyrosine kinase

5

ras

O; colon carcinoma
GP = GTPase

6

L-myc

O; Lung tumor (think L)
GP = transcription factor

7

N-myc

O; Neuroblastoma (think N)
GP = transcription factor

8

ret

O; MEN types 2A, 2B
GP = tyrosine kinase

9

c-kit

O; gastrointestinal stromal tumor (GIST)
GP = cytokine receptor

10

Rb

TS; RetinoBlastoma, osteosarcoma
GP = inhibits E2F; blocks G1 --> S phase
on chrom 13

11

p53

TS; most human cancers, Li-Fraumeni synd
GP = transcription factor for p21, blocks G1 --> S phase

12

BRCA1

TS; breast and ovarian cancer
GP = DNA repair protein

13

BRCA2

TS; breast and ovarian cancer
GP = DNA repair protein

14

p16

TS; melanoma

15

BRAF

O; melanoma
GP = B-raf

16

APC

TS; colorectal cancer (ass. w/ FAP)
gene responsible for cell adhesion --> mut ass w/ decreased D-cadherin adhesion molecule

17

WT1

TS; Wilms' Tumor (nephroblastoma) [think WT]
on chrom 11

18

NF1

TS; NeuroFibromatosis type 1 (think NF1)
GP = RAS GTPase activating protein (RAS-GAP)

19

NF2

TS; NeuroFibromatosis type 2 (think NF2)
GP = merlin (schwannomin) protein

20

DPC4

TS; pancreatic cancer
GP = DPC - "Deleted in Pancreatic Cancer"

21

DCC

TS; colon cancer
GP = DCC - "Deleted in Colon Cancer"

22

PSA

prostrate-specific antigen
used to follow prostate carcinoma; can be elevated in BPH and prostatitis

23

prostate acid phosphatase

prostate carcinoma

24

CEA

CarcinoEmbryonic Antigen
nonspecific; prod by ~70% colorectal and pancreatic cancers
also prod by gastric, breast, medullary thyroid carcinomas
**useful marker for tumor recurrence in colorectal cancer

25

alpha-fetoprotein

hepatocellular carcionas
nonseminomatous germ cell tumors (eg. testis, ovary)

26

beta-hCG

Hydatidiform moles and Choriocarcinomas (Gestational trophoblastic dz)
commonly ass. w/ pregnancy

27

CA-125

ovarian cancer

28

S100

melanoma, neural tumors, schwannomas

29

alkaline phosphatase

metastases to bone, liver, Paget's dz of bone

30

Bombesin

neuroblastoma, lung and gastric cancer

31

TRAP

Tartae-Resistant Acid Phosphatase
Hairy cell leukemia

32

CA-19-9

pancreatic adenocarcinoma

33

calcitonin

medullary thyroid carcinoma

34

K-ras

O; size increases in adenomatous polyps

35

MSH2

DNA repair mismatch
HPNCC, or Lynch synd

36

Erb-B2

encodes protein w/ tyrosine kinase activity related to EGF receptor
overexpression = ass w/ breast/ovarian cancers

37

VHL

TS; del/mut in this gene only ass w/ RCC