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Flashcards in Drugs Deck (38):
1

NNRTIs stand for

Non-Nucleoside Reverse Transcriptase Inhibitor

2

3 drugs that are NNRTI?

Delavirdine, Efavirenz, Nevirapine (Never Ever Deliver Phosphate!)

3

HIV integrase blocker?

Raltegravir

4

What HIV drug boosts other drug conc by inhibiting P-450?

Ritonavir

5

what drug is contraindicated with protease inhibitor b/c it decreases PI conc?

Rifampin

6

HIV drug that causes pancreatitis?

Didanosine

7

what HIV drug has side effects of vivid dreams and CNS symptoms?

efavirenz

8

3 hep C drugs?

ribavirin, simeprevir, sofosbuvir

9

HIV drug that binds to CCR5 and inhibit gp120?

Maraviroc

10

HIV drug that binds to gp41?

Enfuvirtide

11

what HIV drugs don't require phosphorylation?

NNRTIs (Delavirdine, Efavirenz, Nevirapine)

12

what NRTI (Nucleoside) is Nucleotide?

Tenofovir

13

what is the target of natalizumab?

alpha 4 integrin (WBC adhesion)

14

clinical application of natalizumab?

MS, Crohn dz

15

side effects of natalizumab?

risk of PML in pts with JC virus

16

mech of action of ribavirin?

blocks guanine nucleotide synthesis by competitively inhibiting inosine monophosphate dehydrogenase

17

clinical usages of ribavirin?

HCV, RSV

18

In RSV what drug is preferred over ribavirin?

Palivizumab in children

19

which drug blocks the HCV protease inhibitor?

simeprevir

20

which drug blocks HCV RNA-dependent RNA pol?

sofosbuvir

21

what drug is used for acyclovir-resistant HSV that is does not require activation by viral kinase?

forscarnet

22

DOC for P. falciparum resistant to chloroquine?

artemether/lumefantrine or atovaquone/proguanil

23

DOC for life treatening malaria?

use quinidine or artesunate

24

what is the mech of chloroquine?

blocks detoxification of heme into hemozoin --> heme accumulates and is toxic to plasmodia

25

mech of resistance of chloroquine?

due to membrane pump that dec intracellular conc of drug

26

side effects of chloroquine?

retinopathy, pruritius especially in dark skinned ppl

27

what are anti-mite/louse drug used to treat scabies and lice?

Permethrin, Malathion, Lindane

28

mech of Permethrin?

blocks Na+ channel

29

mech of Malathion?

acetylcholinesterase inhibitor

30

mech of Lindane

blocks GABA channels

31

what drug blocks 14 alpha demethylase and inc lanosterol conc?

Azoles

32

which drug blocks the synthesis of sterol?

Azoles

33

drug that blocks squalene epoxidase?

terbinafine

34

2nd gen H1 blockers?

ends with "adine"
loratadine, fexofenadine, desloratadine, cetirizine

35

1st gen H1 blockers?

diphenhydramine, dimenhydrinate, chlorpheniramine

36

aspirin toxicity leads to mixed resp alkalosis and metabolic acidosis, what would be the values of gas panel?

low pCO2 (resp alkalosis) and low bicarb (metabolic acidosis)

37

two methylxanthines (theophylline) toxicities?

cardiotoxicity, neurotoxicity

38

alpha 2 agonist used for glaucoma?

brimonidine