Flashcards in Drugs Deck (38):
NNRTIs stand for
Non-Nucleoside Reverse Transcriptase Inhibitor
3 drugs that are NNRTI?
Delavirdine, Efavirenz, Nevirapine (Never Ever Deliver Phosphate!)
HIV integrase blocker?
What HIV drug boosts other drug conc by inhibiting P-450?
what drug is contraindicated with protease inhibitor b/c it decreases PI conc?
HIV drug that causes pancreatitis?
what HIV drug has side effects of vivid dreams and CNS symptoms?
3 hep C drugs?
ribavirin, simeprevir, sofosbuvir
HIV drug that binds to CCR5 and inhibit gp120?
HIV drug that binds to gp41?
what HIV drugs don't require phosphorylation?
NNRTIs (Delavirdine, Efavirenz, Nevirapine)
what NRTI (Nucleoside) is Nucleotide?
what is the target of natalizumab?
alpha 4 integrin (WBC adhesion)
clinical application of natalizumab?
MS, Crohn dz
side effects of natalizumab?
risk of PML in pts with JC virus
mech of action of ribavirin?
blocks guanine nucleotide synthesis by competitively inhibiting inosine monophosphate dehydrogenase
clinical usages of ribavirin?
In RSV what drug is preferred over ribavirin?
Palivizumab in children
which drug blocks the HCV protease inhibitor?
which drug blocks HCV RNA-dependent RNA pol?
what drug is used for acyclovir-resistant HSV that is does not require activation by viral kinase?
DOC for P. falciparum resistant to chloroquine?
artemether/lumefantrine or atovaquone/proguanil
DOC for life treatening malaria?
use quinidine or artesunate
what is the mech of chloroquine?
blocks detoxification of heme into hemozoin --> heme accumulates and is toxic to plasmodia
mech of resistance of chloroquine?
due to membrane pump that dec intracellular conc of drug
side effects of chloroquine?
retinopathy, pruritius especially in dark skinned ppl
what are anti-mite/louse drug used to treat scabies and lice?
Permethrin, Malathion, Lindane
mech of Permethrin?
blocks Na+ channel
mech of Malathion?
mech of Lindane
blocks GABA channels
what drug blocks 14 alpha demethylase and inc lanosterol conc?
which drug blocks the synthesis of sterol?
drug that blocks squalene epoxidase?
2nd gen H1 blockers?
ends with "adine"
loratadine, fexofenadine, desloratadine, cetirizine
1st gen H1 blockers?
diphenhydramine, dimenhydrinate, chlorpheniramine
aspirin toxicity leads to mixed resp alkalosis and metabolic acidosis, what would be the values of gas panel?
low pCO2 (resp alkalosis) and low bicarb (metabolic acidosis)
two methylxanthines (theophylline) toxicities?