Immunology p213 - 217 Flashcards Preview

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Flashcards in Immunology p213 - 217 Deck (37):
1

name 3 autoantibodies for polymyositis, dermatomyositis?

Anti-Jo-1, anti-SRP, anti-Mi-2

2

name 2 autoantibodies for Hashimoto thyroiditis?

Antimicrosomal, antihyroglobulin

3

autoantibody for autoimmune hepatitis?

anti-smooth muscle

4

what path is associated with anti-Ro, anti-La?

Sjogren syndrome

5

autoantibody for Mixed connective tissue dz?

Anti-U1 RNP (ribonucleoprotein)

6

autoantibody for limited scleroderma (CREST)?

anticentromere

7

autoantibody for scleroderma (diffused)?

anti Scl 70

8

what is another name for anti Scl 70?

anti-DNA topoisomerase 1

9

what path is associated with anti-glutamic acid decarboxylase (GAD 65)?

type 1 DM

10

what immune def dz is associated with chronic diarrhea, thrush, recurrent viral, bacterial, fungal, and protozoal infection?

SCID

11

what is the most common defect in SCID?

defective IL-2R gamma chain

12

what is the CD number for alpha chain of IL-2 receptor?

CD25

13

what T cell has CD25?

Reg T cell

14

CD25 polymorphism is associated with what paths?

autoimmune dz (MS, DM type 1)

15

what path is associated with dec T cell receptor excision circle?

SCID

16

name all the immune def paths that are associated with absent thymic shadow on CXR

Thymic aplasia (DiGeorge) and SCID

17

recurrent viral/fungal infection is mainly due to what type of cell def?

T cell

18

recurrent bacteria/protozoa infection is mainly due to what type of cell def?

B cell

19

name 2 tests that can be used to diagnose chronic granulomatous dz?

1. abnormal dihydrorhodamine (flow cytometry) test
2. neg. nitroblue tetrazolium dye reduction test

20

what is the normal result for nitroblue tetrazolium dye reduction test?

blue, so in CGD the test result is colorless

21

what path is associated with giant granules in granulocytes and platelets, pancytopenia, mild coagulation defects?

chediak higashi syndrome

22

what path is associated with inc AFP, dec in IgA, IgG, IgE?

ataxia telangiectasia

23

what path is associated with def of Th17 cells du to STAT3 mutation?

autosomal dominant hyper IgE syndrome

24

what is another name for autosomal dominant hyper IgE syndrome

Job syndrome

25

what are 2 paths associated with dec IFN gamma?

IL-12 receptor def, Job syndrome (autosomal dominant hyper IgE syndrome)

26

what path is associated with disseminated mycobacterial and fungal infections that may present after administration of BCG vaccines

IL-12 receptor def

27

most common primary immunodef?

selective IgA def

28

define syngeneic graft

graft from identical twin or clone

29

what is the other term for syngeneic graft?

isograft

30

what type of transplant rejection present with vasculitis of graft vessels with dense interstitial lymphocytic infiltrate

acute

31

what type of transplant rejection present with proliferation of vascular smooth muscle and parenchymal fibrosis

chronic

32

what type of transplant rejection is dominant by arteriosclerosis?

chronic

33

give an organ specific example of chronic rejection in the lung

bronchiolitis obliterans

34

give an organ specific example of chronic rejection in the heart

accelerated atherosclerosis

35

give an organ specific example of chronic rejection in the kidney

chronic graft nephropathy

36

give an organ specific example of chronic rejection in the liver

vanishing bile duct syndrome

37

what path is associated with T cells unable to reorganize actin cytoskeleton?

wiskott-aldrich syndrome