Immunology p213 - 217

Question 1

name 3 autoantibodies for polymyositis, dermatomyositis?

Answer 1

Anti-Jo-1, anti-SRP, anti-Mi-2

Question 2

name 2 autoantibodies for Hashimoto thyroiditis?

Answer 2

Antimicrosomal, antihyroglobulin

Question 3

autoantibody for autoimmune hepatitis?

Answer 3

anti-smooth muscle

Question 4

what path is associated with anti-Ro, anti-La?

Answer 4

Sjogren syndrome

Question 5

autoantibody for Mixed connective tissue dz?

Answer 5

Anti-U1 RNP (ribonucleoprotein)

Question 6

autoantibody for limited scleroderma (CREST)?

Answer 6

anticentromere

Question 7

autoantibody for scleroderma (diffused)?

Answer 7

anti Scl 70

Question 8

what is another name for anti Scl 70?

Answer 8

anti-DNA topoisomerase 1

Question 9

what path is associated with anti-glutamic acid decarboxylase (GAD 65)?

Answer 9

type 1 DM

Question 10

what immune def dz is associated with chronic diarrhea, thrush, recurrent viral, bacterial, fungal, and protozoal infection?

Answer 10

SCID

Question 11

what is the most common defect in SCID?

Answer 11

defective IL-2R gamma chain

Question 12

what is the CD number for alpha chain of IL-2 receptor?

Answer 12

CD25

Question 13

what T cell has CD25?

Answer 13

Reg T cell

Question 14

CD25 polymorphism is associated with what paths?

Answer 14

autoimmune dz (MS, DM type 1)

Question 15

what path is associated with dec T cell receptor excision circle?

Answer 15

SCID

Question 16

name all the immune def paths that are associated with absent thymic shadow on CXR

Answer 16

Thymic aplasia (DiGeorge) and SCID

Question 17

recurrent viral/fungal infection is mainly due to what type of cell def?

Answer 17

T cell

Question 18

recurrent bacteria/protozoa infection is mainly due to what type of cell def?

Answer 18

B cell

Question 19

name 2 tests that can be used to diagnose chronic granulomatous dz?

Answer 19

1. abnormal dihydrorhodamine (flow cytometry) test

2. neg. nitroblue tetrazolium dye reduction test

Question 20

what is the normal result for nitroblue tetrazolium dye reduction test?

Answer 20

blue, so in CGD the test result is colorless

Question 21

what path is associated with giant granules in granulocytes and platelets, pancytopenia, mild coagulation defects?

Answer 21

chediak higashi syndrome

Question 22

what path is associated with inc AFP, dec in IgA, IgG, IgE?

Answer 22

ataxia telangiectasia

Question 23

what path is associated with def of Th17 cells du to STAT3 mutation?

Answer 23

autosomal dominant hyper IgE syndrome

Question 24

what is another name for autosomal dominant hyper IgE syndrome

Answer 24

Job syndrome

Question 25

what are 2 paths associated with dec IFN gamma?

Answer 25

IL-12 receptor def, Job syndrome (autosomal dominant hyper IgE syndrome)

Question 26

what path is associated with disseminated mycobacterial and fungal infections that may present after administration of BCG vaccines

Answer 26

IL-12 receptor def

Question 27

most common primary immunodef?

Answer 27

selective IgA def

Question 28

define syngeneic graft

Answer 28

graft from identical twin or clone

Question 29

what is the other term for syngeneic graft?

Answer 29

isograft

Question 30

what type of transplant rejection present with vasculitis of graft vessels with dense interstitial lymphocytic infiltrate

Answer 30

acute

Question 31

what type of transplant rejection present with proliferation of vascular smooth muscle and parenchymal fibrosis

Answer 31

chronic

Question 32

what type of transplant rejection is dominant by arteriosclerosis?

Answer 32

chronic

Question 33

give an organ specific example of chronic rejection in the lung

Answer 33

bronchiolitis obliterans

Question 34

give an organ specific example of chronic rejection in the heart

Answer 34

accelerated atherosclerosis

Question 35

give an organ specific example of chronic rejection in the kidney

Answer 35

chronic graft nephropathy

Question 36

give an organ specific example of chronic rejection in the liver

Answer 36

vanishing bile duct syndrome

Question 37

what path is associated with T cells unable to reorganize actin cytoskeleton?

Answer 37

wiskott-aldrich syndrome