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Flashcards in hematology/immunology Deck (70)
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1

Idiopathic Thrombocytopenia Purpura (ITP) labs

- Normal PT and PTT
- blood smear - enlarged/immature/decreased platelets
- Thrombocytopenia with normal RBC/WBC

2

vitamin K deficiency labs

PT/INR elevated and normal PTT
decreased factors II, VII, IX and X

3

von willebrand disease labs

increased bleeding time, increased PTT
- normal platelets
- decreased factor VIII
- decreased vW antigen

4

what symptom in B12 deficiency is not found in folate deficiency

neurological sx

5

sx same in B12 and folate deficiency

- smooth, sore tongue with atrophy of papillae

6

labs same for alpha thalassemia and beta thalassemia minor

- decreased MCV, Hb and Hct
- Increased RBC count
- Normal RDW, ferritin

7

alpha thalessemia diagnosis

DNA analysis with alpha gene probes is the only way to diagnose

8

alpha thalessemia reticulocytes

normal

9

beta thalassemia major reticulocytes and RDW

increased

10

diagnosis of beta thalassemia

Hb electrophoresis

11

polycythemia vera mutation of what gene

JAK2 gene on chromosome 9

12

polycythemia vera EPO and SAO2 labs

decreased EPO, normal SAO2 (O2 saturation)

13

polycythemia vera labs

- increased RBC count and RBC mass
- decreased EPO, normal SAO2

14

diagnosis of polycythemia vera

3 major criteria OR first 2 major and 2 minor
- Major criteria:
1. increased red cell mass
2. no cause of secondary erythrocytosis
3. palpable splenomegaly
4. JAK2 gene
- Minor:
1. Absolute leukocytosis
2. thrombocytosis
3. leukocytosis
4. low serum EPO
4. Bone marrow Bx reveales myelosis w/ megakaryocytes

15

secondary polycythemia vera can be due to

- high altitude
- COPD
- CVD with R->L shunt
- sleep apnea
- carbon monoxide exposure

16

treatment of polycythemia vera

- phlebotomy
- interferon alpha

17

disseminated intravascular coagulation labs

- increased PT and PTT
- decreased fibrinogen
- thrombocytopenia
- increased bleeding time
- increased D-dimer
- normocytic anemia

18

hemophilia labs

- prolonged PTT, normal INR

19

anti-HIV antibodies are detectable when

3 weeks to 3 months after infection

20

initial screening test for HIV

ELISA (detects anti-gp120 Abs, 100% sensitivity)

21

Confirmatory test for HIV

western blot

22

What is CD4 T cell count used for in HIV

monitoring

23

What is HIV viral load used for in HIV

- detection of dividing virus, marker of disease progression

24

Treatment of HIV

Zidovudine (nucleoside analog reverse transcriptase inhibitors)

25

Ankylosing Spondylitis and Reactive Arthritis HLA

HLA B27 (95% of AS Pts have this; 80% of Reactive arthritis Pts)

26

onset of Sx in Ankylosing Spondylitis usually occurs before what age

40

27

Men or women more common in AS

Men 5x more

28

most common Sx of AS

Uveitis (aka Iritis) = painful red eyes + photophobia, increased lacrimation, blurred vision

29

complications of AS

- restrictive lung disease
- neurological complications

30

imaging findings in AS

- bamboo spine (erosion of vertebral bodies)
- Xray of SI joint shows "psuedowidening" of joint d/t sclerosis