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Flashcards in PHARM interactions and side effects Deck (60)
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1

Hypokalemic drugs

Diuretics (Furosemide, HCTZ)

Corticosteroids (Hydrocortisone, Prednisone, Dexamethasone)

Cardiac glycosides (Digoxin, Convallaria, Digitalis, Leonarus)

Anti-Arrhythmias (atenolol, propranolol, amiodarone)

Pseudoephedrine
Glycyrrhiza

2

What meds caused decreased effects of Amoxicillin

tetracycline (Doxycycline, minocycline - protein synth inhib; mirtazapine - for MDD)

3

Penicillin increases effect and toxicity of what drug

methotrexate

4

Penicillin decreases effect of what drug class

Beta blockers

5

Penicillin's effectiveness is decreased if it's taken with what antibiotic

Doxycycline

6

Cephalexin, a cephalosporin (works like Penicillins), may increase effects of what drug

Metformin

7

A/E of Cephalexin

- C. diff super infection
- diarrhea
- pseudomembranous colitis (higher incidence than other antibiotics)

8

Fluoroquinolone Ciprofloxacin's absorption is decreased by what

cations (antacids, iron, zinc, bismuth)

9

Ciprofloxacin increases serum levels of what drug

warfarin

10

Nitrofurantoin has antagonistic effects with what antibiotic class

Fluoroquinolones (Ciprofloxacin)

11

A/E of Nitrofurantoin

PAIN mnemonic
- Pulmonary toxicity
- Anemia in Pts with G6PD
- Irritated GI
- Neurotoxicity

12

A/E of Doxycyline

- permanent teeth discoloration
- black tongue
- photosensitivity
- GI distress

13

Doxycycline's absorption is reduced when used with

antacids, calcium, Magnesium, Iron

14

Doxycyline decreases effect of what other antibiotic

Penicillin

15

What antibiotic class is safe for pregnancy

Macrolide (Azithromycin)

16

antibiotics that prolong QT

Azithromycin and Ciprofloxacin (macrolide and fluoroquinolone)

17

what kind of antacids reduce rate of absorption of Azithromycin

aluminum and magnesium salts

18

Trimethoprim-Sulfamethoxazole (TMP-SMZ; sulfonamide) induces folate deficiency which causes what Sxs

- thrombocytopenia/leukopenia
- megaloblastic anemia
(these are preventable with folic acid supplement)

19

What other drugs might cause additive folate deficiency with TMP-SMZ

- methotrexate
- phenytoin

20

which antidiabetic drug class does TMP-SMZ affect and how?

Sulphonylureas (increases hypoglycemic effect)

21

What antimicrobial is usually Rx for impetigo

topical Mupirocin

22

condition C/I with topical Mupirocin

burns

23

What anticholinergic antiviral drug is used in parkinsons and herpes zoster (and formerly influenza A)

Amantadine

24

Amantadine enhances effects of what drugs

- anticholinergics and levodopa

25

do not take Amantadine with what type of drugs

CNS stimulants

26

Zidovudine (Antiretroviral) causes what A/E when combined with benzodiazepines

increased incidence of headache

27

interferon alpha is used for treatment of

chronic hep B and C, condyloma acuminatum (genital warts), tumors (leukemia, Kaposi's sarcome (AIDS), malign melanoma)

28

interferon beta is used for treatment of

MS

29

A/E of interferon alpha and beta

Mnemonic IFN ALPHA
- Inhibits bone marrow
- Flu like sxs
- neurotoxic (depression/psychosis)
- autoimmune disorders
- liver enzyme elevations
- proteinuria
- hypotension and tachycardia
- alopecia

30

Fluconazole (Triazole) potentiates what drugs

warfarin and oral hypoglycemics