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Rezi FC > Hepatite > Flashcards

Hepatite Flashcards

1
Q

Cauze hepatita acuta

A

Infectii virale
* Hepatitice (toate)
* EBV
* CMV
* Virusul febrei galbene
* altele - rar
Infectii NON-virale
* Toxoplasma gondii
* Coxiella burnetii (febra Q)
* Leptospira icterohaemorrhagiae
Alcool
Medicamente - paracetamol
Toxice/otravuri
* Amanita phalloides
* Aflatoxina (Aspergillus flavus)
* Tetraclorura de carbon
Alte cauze
* Sarcina
* Boala Wilson
* Insuficienta circulatorie

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2
Q

Cauze hepatita cronica

A

Virala
* VHB +/- VHD
* VHC
* VHE (imunocompromisi)
Medicamente
* Metildopa
* Izoniazida
* Nitrofurantoina
* Ketoconazol
Metabolica - NAFLD = steatoza hepatica non-alcoolica
Alcoolica
Autoimuna
Ereditara - boala Wilson, hemocromatoza
Cauze neobisnuite
* Infectii - sifilis, TB, infectii tropicale
* Boli infiltrative - amiloidoza
* Limfom
* Toxine

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3
Q

Dimensiuni virusuri hepatitice (nm)

A

VHA = 27-32
VHE = 27-35
VHD = 36 (cu invelis AgHBs)
VHB = 42
VHC = 50

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4
Q

Complicatii extrahepatice VHA

A

Artrita
Vasculita
Miocardita
IRA

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5
Q

Prevalenta VHC

A

0.4% Europa
1-3% Europa Sudica
6% Africa
19% Egipt

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6
Q

Incidenta HVC la dependentii de droguri i.v

A

Crescuta = 40-60%

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7
Q

Distributie geografica VHC pe genotipuri

A

1a, 1b = SUA 70%, Europa 50%
3 = India
4 = Egipt

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8
Q

Inhibitori de NS3/4

A

Glecaprevir
Grazoprevir
Voxilaprevir
Paritaprevir
Simeprevir

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9
Q

Inhibitori de NS5A

A

Velpatasvir
Ledipasvir
Pibrentasvir
Elbasvir
Daclatasvir

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10
Q

Inhibitori de NS5B = ARNpol

A

Nucleotidici - sofosbuvir
Non-nucleotidici - dasabuvir

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11
Q

Manifestari extrahepatice in HVC

A

Artrita
CG +/- GN
Porfiria cutanea tarda
Lichen plan

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12
Q

Cu ce boli se asociaza HVC

A

Sindrom sicca
LNH

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13
Q

HVC creste incidenta de

A

DZ

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14
Q

Factorii asociati cu o progresie rapida a fibrozei VHC

A

Obezitate
DZ
Alcool
Coinfectie VHC-HIV
Genotipul 3

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15
Q

Beneficiile in curs de urmarire ale vindecarii VHC dpdv al sanatatii publice

A

Mai putine persoane infectate
Eliminarea VHC la populatiile la risc (consumatorii de droguri i.v)

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16
Q

Ce persoane trebuie vaccinate de hepatita A?

A

Hemofilie
Hepatopatie cronica
Calatorii frecvente in zone endemice
Lucratorii cu contact frecvent cu cazuri de hepatita - institutii rezidentiale pentru pacienti cu dificultati de invatare

17
Q

Componenta antigenica majora a VHA este asociata cu

A

VP1

18
Q

Polipeptidele capsidei VHA

A

VP1 -> VP4
Peptide structurale din capatul N-terminal al polipeptidului viral sintetizat in celula gazda

19
Q

Cadrele de citire ale genomului VHE

A

ORF1 - codifica proteinele NON-structurale
* Metil-transferaza
* Cistein-proteaza
* ARN-replicaza

ORF2 - codifica proteinele structurale
Contine peptid semnal si locuri de glicozilare

ORF3 - codifica un peptid hidrofob cu rol nedeterminat

20
Q
A

Rezi FC (28 decks)

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