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Immune Micro 3 > Hepatitis > Flashcards

Flashcards in Hepatitis Deck (38):
1

immunity to Hep A

no chronic infection, infection confers lifelong immunity

1

tissue culture system for Hep B

none

2

virology Hep E

enteric virus

calicivirus family

+sense single strand RNA

icosahedral

2

chronic Hep C infection prone to hepatic carcinoma because

core protein interacts with p53, Rb tumor suppressors and pathways involved in proliferation

 

core protein induces steatosis

envelope protein inhbits natural NK cells

non-structural proteins can enhance cell growth

3

steatosis in Hep C

core protein induces lipid accumulation leading to fatty acid spiral > oxidative stress and cell Proliferation > accerated HCC

4

tissue culture system Hep A

none

4

entrance of Hep D (delta agent) increaes liklihood of

fulinant hepatitis

5

transmission Hep A

fecal oral

5

Hep B virions enveloped and released with

shedding of surface antigens

6

Hep A viral shedding occurs

before symptoms emerge

7

rare complcations, chronic sequelae Hep A

fulminant hepatitis, cholestatic hepatits, relaspsing hepatitis,

 

no chronic sequela

7

role in Hep B HCC "x protein"'

decreaes p53 guardian of genome activity

8

Hep B chronic infection occurs in 

infants

9

Clinical presentations Hep B

Fever, rash arthritis

Jaundice

dark urine

Malaise, Anorexia, nausea, RUQ pain

11

serotypes Hep A

single serotype

12

Hep D virology

virioid

small RNA copid by host RNA pol II

encodes 1 antigen, packages in Hep B sAg

15

Hep C liverr damage due to

viral replciation inducing robsust innate immune resposne

16

once naive lymphocytes have responded with 10-15 cell divisions, they must

rest, and can be stimualted to proliferate again later (principle of boosters)

17

outbreaks of hep E due to

contaminated water

17

Nonfectious particles produced by Hep B infected cells

HbsAg particles

18

reccodmended for Hep A vaccination

infants

travels to HIV area

Chronic Liver disease

working with HAV

19

Hep A vaccine

inactivated with formalin

cell culture grown in human fibroblasts

aluminum adjuvant

20

___ and ___ eliminate Hep A infected cells, Ab response assists in viral clearance

NK and cytotoxic T cells 

21

Hep C infection requires ___ that regulates mRNAs in a sequence specific manner, the most common enhancing translation and replication

miRNA

22

hep B virus receptor

sodium/bile acid cotransporter (NTCB)

23

Genome-wide association study pointed to ___- gene in outcome of HCV infection

IL28 B, econdes antiviral cytokine IFN lambda

24

Hep A virology

+ strand icosahedral

RNA virus

Capsid stable to acid, drying detergens

25

incubation period hep B

2 months

26

Hep D, clinical features (2 courses)

Coinfection - severe acute disease and low risk of chronic infection

 

superinfection (later infection with Hep B - chronic infection likely, high risk severe chronic liver disease

 

28

Hep __ rearranges intracellular mmebranes as a platform for replication

Hep C

29

Hep C encodes multiple ____ enable virus persistancee

immunomodulaters

31

Hep C virus often associated with cellular ___-

VLDL

32

Hep C virology

flavivirus

pos stran RNA

enveloped proteins

Error prone polymerase

33

effective cell-mediated response to hep B leads to

acute disease and resolution

35

Virology Hep B (Hepadnavirus)

enveloped

circular DNA genome, partly double strnaded

mRNA reverse transcribed to partially DS DNA

36

chonic Hep B causes hepatocellular carinoma because

liver injury > cell proliferation  > viral DNA in host DNA causes genomic instability

virally encoded X protein

37

Hep D can only grow in

Hep B infected Cells

38

Hep A incubation period

30 days