Hepatitis

Question 1

immunity to Hep A

Answer 1

no chronic infection, infection confers lifelong immunity

Question 1

tissue culture system for Hep B

Answer 1

none

Question 2

virology Hep E

Answer 2

enteric virus

calicivirus family

+sense single strand RNA

icosahedral

Question 2

chronic Hep C infection prone to hepatic carcinoma because

Answer 2

core protein interacts with p53, Rb tumor suppressors and pathways involved in proliferation

core protein induces steatosis

envelope protein inhbits natural NK cells

non-structural proteins can enhance cell growth

Question 3

steatosis in Hep C

Answer 3

core protein induces lipid accumulation leading to fatty acid spiral > oxidative stress and cell Proliferation > accerated HCC

Question 4

tissue culture system Hep A

Answer 4

none

Question 4

entrance of Hep D (delta agent) increaes liklihood of

Answer 4

fulinant hepatitis

Question 5

transmission Hep A

Answer 5

fecal oral

Question 5

Hep B virions enveloped and released with

Answer 5

shedding of surface antigens

Question 6

Hep A viral shedding occurs

Answer 6

before symptoms emerge

Question 7

rare complcations, chronic sequelae Hep A

Answer 7

fulminant hepatitis, cholestatic hepatits, relaspsing hepatitis,

no chronic sequela

Question 7

role in Hep B HCC “x protein”’

Answer 7

decreaes p53 guardian of genome activity

Question 8

Hep B chronic infection occurs in

Answer 8

infants

Question 9

Clinical presentations Hep B

Answer 9

Fever, rash arthritis

Jaundice

dark urine

Malaise, Anorexia, nausea, RUQ pain

Question 11

serotypes Hep A

Answer 11

single serotype

Question 12

Hep D virology

Answer 12

virioid

small RNA copid by host RNA pol II

encodes 1 antigen, packages in Hep B sAg

Question 15

Hep C liverr damage due to

Answer 15

viral replciation inducing robsust innate immune resposne

Question 16

once naive lymphocytes have responded with 10-15 cell divisions, they must

Answer 16

rest, and can be stimualted to proliferate again later (principle of boosters)

Question 17

outbreaks of hep E due to

Answer 17

contaminated water

Question 17

Nonfectious particles produced by Hep B infected cells

Answer 17

HbsAg particles

Question 18

reccodmended for Hep A vaccination

Answer 18

infants

travels to HIV area

Chronic Liver disease

working with HAV

Question 19

Hep A vaccine

Answer 19

inactivated with formalin

cell culture grown in human fibroblasts

aluminum adjuvant

Question 20

___ and ___ eliminate Hep A infected cells, Ab response assists in viral clearance

Answer 20

NK and cytotoxic T cells

Question 21

Hep C infection requires ___ that regulates mRNAs in a sequence specific manner, the most common enhancing translation and replication

Answer 21

miRNA

Question 22

hep B virus receptor

Answer 22

sodium/bile acid cotransporter (NTCB)

Question 23

Genome-wide association study pointed to \_\_\_- gene in outcome of HCV infection

Answer 23

IL28 B, econdes antiviral cytokine IFN lambda

Question 24

Hep A virology

Answer 24

+ strand icosahedral RNA virus Capsid stable to acid, drying detergens

Question 25

incubation period hep B

Answer 25

2 months

Question 26

Hep D, clinical features (2 courses)

Answer 26

Coinfection - severe acute disease and low risk of chronic infection superinfection (later infection with Hep B - chronic infection likely, high risk severe chronic liver disease

Question 28

Hep __ rearranges intracellular mmebranes as a platform for replication

Answer 28

Hep C

Question 29

Hep C encodes multiple ____ enable virus persistancee

Answer 29

immunomodulaters

Question 31

Hep C virus often associated with cellular \_\_\_-

Answer 31

VLDL

Question 32

Hep C virology

Answer 32

flavivirus pos stran RNA enveloped proteins Error prone polymerase

Question 33

effective cell-mediated response to hep B leads to

Answer 33

acute disease and resolution

Question 35

Virology Hep B (Hepadnavirus)

Answer 35

enveloped circular DNA genome, partly double strnaded mRNA reverse transcribed to partially DS DNA

Question 36

chonic Hep B causes hepatocellular carinoma because

Answer 36

liver injury \> cell proliferation \> viral DNA in host DNA causes genomic instability virally encoded X protein

Question 37

Hep D can only grow in

Answer 37

Hep B infected Cells

Question 38

Hep A incubation period

Answer 38

30 days