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Flashcards in Host response Deck (20):
1

IL 12 promotes

NK producition of IFNy, differentiation to Th1

1

viruses encode ___ to inhibit apototic cascade 4

viral Bcl-2, vTNF-Rs, p53 inhibitors, v-vaspase inhibitors

2

TNF factor induces ___ and ____

fever and death signaling

3

IFNa/b signaling occurs at___ to activate ___

JAK/STAT pathway receptors to activate PKR and 2'5'oligoadenylate synthase

3

____ encode its own strucutred RNA binds to PKR and inhibits activation by dsRNA

adnovirus

4

modes of impacting MHC and NK ligand expression (4)

block tap transporter to prevent MHC folding in ER AND bind class I and cause retrotranslocation to ER and degradation AND bind class I in ER and prevent translocation to golgi AND bind class I in ER and route to lysosome

5

NK cell activity enhance by

IFNs and IL-12

6

NK cell kills after assessing balance between 2 signals

inhibitory signals from class I, activating signals from NK activating ligands

8

PKR phosphorlates ___ which deactivates its dilivery of Met tRNA to ribosome, preventing protein translation

elF-2a

9

IFN a used in treatment of

chronic hep c

10

pox viruses encode dsRNA binding proteins that sequester dsRNA and prevent

PKR activation

11

OAS is activated by ___, which catalyzes synthesis of oligo adenylate from ATP which activates ____ an endoribunuclease to degrade mRNA

OAS is activated by double-stranded RNA, which catalyzes synthesis of oligo adenylate from ATP which activates RNAse L an endoribunuclease to degrade mRNA

12

IFN b used in treatment of

MS

12

POx viruses encode ____ that bind PKR and prevent it from phosphorylating elF2a

elF2a decoy

13

pro inflammatory cytokines 3

TNF, IL-1B, IL-6

15

pox viruses encode proteins to prevent

IFN binding

17

antiviral state leads to increased ____ and -___ and decreased ___

increased MHC I and NK cells, decreased viral protein synthesis

18

synthesis of IFNa/b leads to

introduction of antiviral state in nearby cells

19

IL 2 promotes

NK proliferation, T cell proliferation

20

First host response to viral infection

IFNa/b (type 1 IFNs)