Retroviruses Flashcards Preview

Immune Micro 3 > Retroviruses > Flashcards

Flashcards in Retroviruses Deck (14):
1

capsid core made up of structural proteins product of

gag gene

1

Reverse transcriptase 2 polymerase functions

1) RNA dependent DNA pol (RNA to DNA) AND 2) DNA dependent DNA pol (second strand of DNA from first strand)

1

integrase recognizes

sequences at ends of U3 and U5

2

gp160 precursor protein cleaved to ____, must happen because gp160 cannot support membrane fusion

gp120 gp41

3

U3 contains binding sites for ____ required for high level RNA synthesis

cellular transcription factors

4

env protein made from

spliced mRNA on ER bound ribosomes

5

stages of replication cycle

1) absorption 2) penetration and uncoating 3) reverse transcription 4) transit to nucleus 5) integration to host DNA 6) viral RNA synthesis via host pol II 6) RNA processing 7) Virion protein synthesis 8) assembly and budding 9) capsid maturation (proteolysis) (All Problem Residents Never Involve Reallystupid ResidentProgramss, PS, Are Cunts)

7

differing factors complex retrovirus genome

mRNA for additional accessory proteins

8

contents of coding region of retrovirus genome

Gag gene, polymerase genes, envelope gene

10

genomic regions common to all retroviruses

R repeat at each end AND U5 AND Coding Region AND U3 region AND R region

11

virion has 2 copies of ___, unique to retroviruses

+ssRNA genome

12

integrated DNA, the ____, is longer than template RNA and has U3 and U5 duplicated at ends to form ___

integrated DNA, the Provirus, is longer than template RNA and has U3 and U5 duplicated at ends to form Long Terminal Repeats

13

protein that becomes associated with dsDNA responsible for viral DNA integration

integrase

14

signal for packaging found in unspliced by not spliced RNA

Psi signal