Viruses of childhood

Question 1

atypical measles

Answer 1

intense rash, vesicles, petechiae, prurpura or urticaria

Question 2

erythema infectiosum =

Answer 2

parvovirus B19

Question 2

RotaTeq vaccine

Answer 2

life attenuate vaccine, human bovine reassortant,

oral, 3xbetween 2, 4 6 months

Question 3

parvovirus B19 complciations

Answer 3

anemia due to reduced cell number and hemoglobin

aplastic crisis due to RBC loss

transmission to fetus > still brith, edam (detal hydrops) anemia, CHF, no abnormalities

Question 4

subacute sclerosing panencephalitis

Answer 4

measles

CNS perosnality, behavior memory changes

myoclonc jerks, spasticity

blindness

Question 4

newly discovered parvovirus resposnible for repiratory and GI infections

Answer 4

bocavirus

Question 4

parvovirus internalized via

Answer 4

coated pits

Question 5

parvovirus B19 clinical

Answer 5

eryhtma infectiosum (fifths disease)

red cheeks, maculopapu;ar rash

circulating immune complexes > rash, athralgia, arthritis, but do not fix complement

Question 6

congenital rubella syndrome

Answer 6

cataracts

heart defects

deafness

growth + mental retardation

FTT

mortality

microencephaly

Question 7

key to meales, mumps, rubella vaccination effectiveness

Answer 7

single antigenic type (infection prevents reinfection)

systemic replication prior to infecting target ogan - antibodies can limit or block at this stage

Question 7

measles pathogenesis

Answer 7

respiration

lymphatic spread > viremia

conjunctivae, respiratory, urinary tract, vessels, lymph, cns

Virus infected endothelial cells plus immune Tcells

Rash

Recovery + immunity

Question 8

post measeles encephalitis

Answer 8

acute onset of headache, vonfuion, voimitiung, coma after rash dissipates

Question 9

major enterovirus groups resonsible for paralytic disease, encephalitis meningitis, RTI, undifferenciated fever

Answer 9

Poliovirus,

coxsackie A and B virus

Echnoviruses

Question 10

parvovirus infection location, recepotr

Answer 10

actively replicated RBC progenitors in marrow (viremia)

receptor is blood gorup P antigen (globoside)

Question 11

antigen group of Rota virus most common cause of human disease

Answer 11

group A (VP6 subgroup)

Question 12

rubella (german measles) =

Answer 12

togavirus

Question 13

targets for norovirus therapy

Answer 13

protease, viral pomyerase

structural porteins target for virus like particle Vaccines

Question 15

chicken pox =

Answer 15

varcilla zoster virus

Question 16

norovirus reinfection due to

Answer 16

lack of lasting immunity, strain diversity

Question 17

enterovirus pathogensis

Answer 17

fecal/oral or resp

rplication in oropharynx and GI

viremic phase to target tissue (antibody can block before(

possible secondary viremeia

Question 18

Rotatrix vaccine

Answer 18

live attenuated singel human strain

oral 2x 2 and 4 months

Question 19

mumps clinical sypmtoms

Answer 19

parotitis

swelling of glands (ochrtitis, mastitis, pancreatitis, throiditis)

CNS involvement

(mild meningitis and rare encephalitis)

Question 20

rare outcomes measles

Answer 20

post-infectious encephalitis

subacute sclerosing pnenncephalitis (CNS)

no resolution of acute infection caused by defective CMI (often fatal)

Question 21

entero toxin of rotavirus, role

Answer 21

NSP4 - receptor on cells > signaling events lead to increase in intracellular Ca >> tight junction interference

also stimulates enteric nerves > stimulate goblet cells > stmulate Cl release >diarrhea

Question 23

Parvovirus replication requirements

Answer 23

host S phase uses cellular DNA pol

Question 24

rotavirus virology

Answer 24

11 ds RNA segements, 12 genes no envelope 3 layer capsid multple antigenic groups A E

Question 25

hand foot, mouth disease, viruses and symptoms

Answer 25

Coxsackie A and Enterovirus 71 mild fever, sore through vesicular lesions fatigue and loss of apeptite

Question 26

MMR measles mumps rebella vaccine

Answer 26

live, attenuated combination blocks virus during systemic stage and prevents infection of target organ

Question 27

symptoms measues

Answer 27

cough, conjunctivitis, coryza, photpobia, koplik spots (otitis media, croup pneumonia, blindness, encephalitis complications)

Question 28

rubella virology

Answer 28

togavirus, only infects humans one serotype

Question 29

adult meningitis symptoms

Answer 29

headache fever chills nausea vomiting still meck light sensitiity

Question 30

roseola (exanthem subitum) =

Answer 30

human herpes virus 6

Question 31

measles (rubeola) =

Answer 31

paramyxovirus

Question 33

parvovirus B19 morphology

Answer 33

ss DNA virus nonenveloped iscosohedral replicates in nuclues dependent on host DNA replciation

Question 34

infant symptoms meningitis

Answer 34

fever irritability poor eating hard to awaken

Question 35

mumps pathogenesis

Answer 35

resp epithelium local replication and viremia infection of parotid gland and CNS inflammation adn swelling \> sweeling of other glands pancrease (associated with juvenile diabetes?)