Viruses of childhood Flashcards Preview

Immune Micro 3 > Viruses of childhood > Flashcards

Flashcards in Viruses of childhood Deck (36):
1

atypical measles

intense rash, vesicles, petechiae, prurpura or urticaria

2

erythema infectiosum = 

parvovirus B19

2

RotaTeq vaccine

life attenuate vaccine, human bovine reassortant, 

oral, 3xbetween 2, 4 6 months

3

parvovirus B19 complciations

anemia due to reduced cell number and hemoglobin

aplastic crisis due to RBC loss

transmission to fetus > still brith, edam (detal hydrops) anemia, CHF, no abnormalities

4

subacute sclerosing panencephalitis

measles

 

CNS perosnality, behavior memory changes

myoclonc jerks, spasticity

blindness

4

newly discovered parvovirus resposnible for repiratory and GI infections

bocavirus 

4

parvovirus internalized via

coated pits

5

parvovirus B19 clinical

eryhtma infectiosum (fifths disease)

red cheeks, maculopapu;ar rash

circulating immune complexes > rash, athralgia, arthritis, but do not fix complement

6

congenital rubella syndrome

cataracts

heart defects

deafness

growth  + mental retardation

FTT

mortality

microencephaly

7

key to meales, mumps, rubella vaccination effectiveness

single antigenic type (infection prevents reinfection)

 

systemic replication prior to infecting target ogan - antibodies can limit or block at this stage

7

measles pathogenesis

respiration

lymphatic spread > viremia

conjunctivae, respiratory, urinary tract, vessels, lymph, cns

Virus infected endothelial cells plus immune Tcells

Rash

Recovery + immunity

8

post measeles encephalitis

acute onset of headache, vonfuion, voimitiung, coma after rash dissipates

9

major enterovirus groups resonsible for paralytic disease, encephalitis meningitis, RTI, undifferenciated fever

Poliovirus,

coxsackie A and B virus

Echnoviruses

10

parvovirus infection location, recepotr

actively replicated RBC progenitors in marrow (viremia)

 

receptor is blood gorup P antigen (globoside)

11

antigen group of Rota virus most common cause of human disease

group A (VP6 subgroup)

12

rubella (german measles) = 

togavirus

13

targets for norovirus therapy

protease, viral pomyerase

 

structural porteins target for virus like particle Vaccines

15

chicken pox = 

varcilla zoster virus

16

norovirus reinfection due to 

lack of lasting immunity, strain diversity

17

enterovirus pathogensis

fecal/oral or resp

rplication in oropharynx and GI

viremic phase to target tissue (antibody can block before(

possible secondary viremeia

18

Rotatrix vaccine

live attenuated singel human strain

oral 2x 2 and 4 months

19

mumps clinical sypmtoms

parotitis

swelling of glands (ochrtitis, mastitis, pancreatitis, throiditis)

 

CNS involvement

(mild meningitis and rare encephalitis)

20

rare outcomes measles

post-infectious encephalitis

 

subacute sclerosing pnenncephalitis (CNS)

 

no resolution of acute infection caused by defective CMI (often fatal)

21

entero toxin of rotavirus, role

NSP4 - receptor on cells > signaling events lead to increase in intracellular Ca >> tight junction interference

also stimulates enteric nerves > stimulate goblet cells > stmulate Cl release >diarrhea

23

Parvovirus replication requirements

host S phase

 

uses cellular DNA pol 

24

rotavirus virology

11 ds RNA segements, 12 genes

no envelope

3 layer capsid

multple antigenic groups A E

25

hand foot, mouth disease, viruses and symptoms

Coxsackie A and Enterovirus 71

mild fever, sore through

vesicular lesions

fatigue and loss of apeptite

26

MMR measles mumps rebella vaccine

live, attenuated combination

 

blocks virus during systemic stage and prevents infection of target organ 

27

symptoms measues

cough, conjunctivitis, coryza, photpobia, koplik spots

 

(otitis media, croup pneumonia, blindness, encephalitis complications)

28

rubella virology

togavirus, only infects humans

one serotype

29

adult meningitis symptoms

headache

fever chills 

nausea vomiting

still meck light sensitiity

30

roseola (exanthem subitum) =

human herpes virus 6

 

31

measles (rubeola) =

paramyxovirus

33

parvovirus B19 morphology

ss DNA virus

nonenveloped iscosohedral

replicates in nuclues

dependent on host DNA replciation

34

infant symptoms meningitis

fever

irritability

poor eating

hard to awaken

35

mumps pathogenesis

resp epithelium 

local replication and viremia

infection of parotid gland and CNS

inflammation adn swelling > sweeling of other glands

pancrease (associated with juvenile diabetes?)