Lymphotropic viruses

Question 1

presentation cytomegalovirus persistent infections

Answer 1

atherosclerosis, immunosenescence, neuroblastoma

Question 1

CMV does not encode ____ making acyclovir ineffective

Answer 1

thymidine kinase

Question 1

HHV-6b replication in

Answer 1

CD4 Tcells (latency site unknown)

Question 1

EBV latency II displays ___ antigens

Answer 1

EBNA1, LMP1, LMP2A, RNA EBER&2

Question 1

HHV8 Kaposis sarcoma gamma herpesvirus replication in

Answer 1

CD19 B cells, endothelial cells, monocytes, keratinocytes, epithial cells

Question 2

Herpesvirus 6b HHV-6b genome

Answer 2

dsDNA

Question 3

congentialCMV permanent symptoms

Answer 3

hearing loss, vision loss, retardation, musculoskeletal abnormalities, seizures, septal defects

Question 4

Beta herpes viruses

Answer 4

cytomegalovirus Herpevirus-6a, Heprevirus-6b, Herpevirus-7

Question 4

viral characteristics cytomegalovirus

Answer 4

dsDNA, immediate, early, late stages of gene expression. Enveloped, icosahedral nucleocapsid, tegument proteins and RNA

Question 4

serology of EBV, identify heterophile antibodies via

Answer 4

capability to agglutinate animal RBCs

Question 6

CMV symptoms at birth

Answer 6

lesions, small size, hepatosplenomegaly, jaundice, hemolytic anemia, pneumonia, intracranial calcifications, microcephaly

Question 7

CMV lytic replication in

Answer 7

epithelial, dendritic, fibroblast, smooth muscle, endothelial, macrophages, trophoblast

Question 9

EVB mediated B cell proliferative disease activated by immunosuppression

Answer 9

Post transplant lymphoproliferative disorder

Question 10

presentation cytomegalovirus health adults

Answer 10

asymptomiatic in healthy adults (mild mononucleosis)

Question 11

EBV disease

Answer 11

infectious mononucleosis, Post transplant lymphoproliferative disorder, Lymphomas (B, T and NK cell)

Question 12

presentation cytomegalovirus - birth defects

Answer 12

mental retardation, deafness, death

Question 13

EBV lymphoma, EBV DNA in epithelial tumor cells, China, alska, tunisa and E Africa

Answer 13

Nasopharyngeal epithelia carinoma

Question 14

HHV8 disease

Answer 14

Kapsosi sarcoma endothelial derived neoplasm, primary effusion lymphoma, multicentric Castleman disease

Question 15

cytomegalovirus latency in

Answer 15

macrophages

Question 16

gamma herpes viruses

Answer 16

Epstien Barr, Kaposi’s Sacrcoma virus

Question 17

EBV latency II and III

Answer 17

viral antigens made in memory B cells, can lead to Burkits, Hodkin lymphoma, nasopharyngeal carcinoma

Question 18

EBV mono results from rapid proliferation of

Answer 18

atypical T cells, (downey cells)

Question 19

EBV transmission

Answer 19

saliva and blood, limited to epitheliam of pharynx and bcells due to restricted cellular expression

Question 20

Treatment CMV

Answer 20

Granciclovir or valganciclovir OR Foscarnet OR Cidofovir

Question 21

HHV 8 charactersitics

Answer 21

dsDNA, common in Africa

Question 23

immune response to CMV

Answer 23

innate macrophage/NK/IFN response insufficient. Humoral does not clear but can limit reinfection or reactivation. Cytotoxic Tcells kill CMV infected cells (immune response cannot completely control)

Question 24

EBV latency I displays ___ antigens

Answer 24

EBNA1 RNA EBER&2

Question 26

cytomegaalovirus transmission

Answer 26

semen/cervical secretion/blood/milk/tears/urine/feces/saliva./transplacental

Question 27

EBV lymphoma in immunosupressed and trasplant patients

Answer 27

Polyclonal lymphoma, lymphocytic interstitial pneumonia, Hairy oral leukoplakia of the tongue

Question 28

EBV ___ tethers viral genome to host chromosome

Answer 28

EBNA1

Question 29

EBV lymphoma, B cell lympomas

Answer 29

Hodkin and non-Hodgkin lymphoma

Question 31

epstein barr, kaposi's sarcoma virus latency in

Answer 31

plasma cells

Question 33

primary infection EBV mono due to

Answer 33

robust expansion of Tcells, atypical or Downey Tcells

Question 34

EBV latency I

Answer 34

antigens made in proliferating B ells, infectious mono, post transplant lymphoproliferative disorder

Question 35

gamma herpes virus HHV-8 =

Answer 35

Kaposis sarcoma herpesvirus

Question 36

EBV dissemination phase, B cells produce

Answer 36

heterophile antibodies (non functional)

Question 37

cytomegalovirus shedding starts at

Answer 37

1 month post infection, can last months - 1 year

Question 37

CMV infection symptoms

Answer 37

fever, fatigue, sore throut, liver function abnormalities, lymphocytosis, lymphadenopathy, mononucleosis (heterophile antibody negative)

Question 39

EBV, loss of T cell function results in ____ diseases

Answer 39

b cell proliferation of disease

Question 40

HHV-6b clinical disease

Answer 40

exanthem subitum or roseola infantum, fever, malaise, lympadenopathy, rash after fever break, no sequalae

Question 41

mononucleosis in CMV infection is ___ antibody negative

Answer 41

antibody negative

Question 42

cytomegalovirus infected cells show

Answer 42

owl eye, inclusion body

Question 43

Ebstein Barr virus characteristics

Answer 43

dsDNA, nucleocapsid, tegument and envelope with glycoproteins, 3 stage gene expression

Question 44

EBV lymphoma, B cell lymphoma of jaw and face, children 5-10, IgG promoter myc proto-oncogene, Associated with chromosomal translocation

Answer 44

Burkitt's lymphoma

Question 45

Roseolovirus (HHV-6) latency in

Answer 45

T-lymphocytes

Question 46

diagnosis CMV

Answer 46

IgM testing variable, IgG avidity increases with time to define primary infection and recent vs past. Viral DNA, culture and immunofluorescence

Question 47

CMB latent infection in

Answer 47

CD34+ hematopoeitic progenitor cells, monocytes