Lymphotropic viruses Flashcards Preview

Immune Micro 3 > Lymphotropic viruses > Flashcards

Flashcards in Lymphotropic viruses Deck (47):
1

presentation cytomegalovirus persistent infections

atherosclerosis, immunosenescence, neuroblastoma

1

CMV does not encode ____ making acyclovir ineffective

thymidine kinase

1

HHV-6b replication in

CD4 Tcells (latency site unknown)

1

EBV latency II displays ___ antigens

EBNA1, LMP1, LMP2A, RNA EBER&2

1

HHV8 Kaposis sarcoma gamma herpesvirus replication in

CD19 B cells, endothelial cells, monocytes, keratinocytes, epithial cells

2

Herpesvirus 6b HHV-6b genome

dsDNA

3

congentialCMV permanent symptoms

hearing loss, vision loss, retardation, musculoskeletal abnormalities, seizures, septal defects

4

Beta herpes viruses

cytomegalovirus Herpevirus-6a, Heprevirus-6b, Herpevirus-7

4

viral characteristics cytomegalovirus

dsDNA, immediate, early, late stages of gene expression. Enveloped, icosahedral nucleocapsid, tegument proteins and RNA

4

serology of EBV, identify heterophile antibodies via

capability to agglutinate animal RBCs

6

CMV symptoms at birth

lesions, small size, hepatosplenomegaly, jaundice, hemolytic anemia, pneumonia, intracranial calcifications, microcephaly

7

CMV lytic replication in

epithelial, dendritic, fibroblast, smooth muscle, endothelial, macrophages, trophoblast

9

EVB mediated B cell proliferative disease activated by immunosuppression

Post transplant lymphoproliferative disorder

10

presentation cytomegalovirus health adults

asymptomiatic in healthy adults (mild mononucleosis)

11

EBV disease

infectious mononucleosis, Post transplant lymphoproliferative disorder, Lymphomas (B, T and NK cell)

12

presentation cytomegalovirus - birth defects

mental retardation, deafness, death

13

EBV lymphoma, EBV DNA in epithelial tumor cells, China, alska, tunisa and E Africa

Nasopharyngeal epithelia carinoma

14

HHV8 disease

Kapsosi sarcoma endothelial derived neoplasm, primary effusion lymphoma, multicentric Castleman disease

15

cytomegalovirus latency in

macrophages

16

gamma herpes viruses

Epstien Barr, Kaposi's Sacrcoma virus

17

EBV latency II and III

viral antigens made in memory B cells, can lead to Burkits, Hodkin lymphoma, nasopharyngeal carcinoma

18

EBV mono results from rapid proliferation of

atypical T cells, (downey cells)

19

EBV transmission

saliva and blood, limited to epitheliam of pharynx and bcells due to restricted cellular expression

20

Treatment CMV

Granciclovir or valganciclovir OR Foscarnet OR Cidofovir

21

HHV 8 charactersitics

dsDNA, common in Africa

23

immune response to CMV

innate macrophage/NK/IFN response insufficient. Humoral does not clear but can limit reinfection or reactivation. Cytotoxic Tcells kill CMV infected cells (immune response cannot completely control)

24

EBV latency I displays ___ antigens

EBNA1 RNA EBER&2

26

cytomegaalovirus transmission

semen/cervical secretion/blood/milk/tears/urine/feces/saliva./transplacental

27

EBV lymphoma in immunosupressed and trasplant patients

Polyclonal lymphoma, lymphocytic interstitial pneumonia, Hairy oral leukoplakia of the tongue

28

EBV ___ tethers viral genome to host chromosome

EBNA1

29

EBV lymphoma, B cell lympomas

Hodkin and non-Hodgkin lymphoma

31

epstein barr, kaposi's sarcoma virus latency in

plasma cells

33

primary infection EBV mono due to

robust expansion of Tcells, atypical or Downey Tcells

34

EBV latency I

antigens made in proliferating B ells, infectious mono, post transplant lymphoproliferative disorder

35

gamma herpes virus HHV-8 =

Kaposis sarcoma herpesvirus

36

EBV dissemination phase, B cells produce

heterophile antibodies (non functional)

37

cytomegalovirus shedding starts at

1 month post infection, can last months - 1 year

37

CMV infection symptoms

fever, fatigue, sore throut, liver function abnormalities, lymphocytosis, lymphadenopathy, mononucleosis (heterophile antibody negative)

39

EBV, loss of T cell function results in ____ diseases

b cell proliferation of disease

40

HHV-6b clinical disease

exanthem subitum or roseola infantum, fever, malaise, lympadenopathy, rash after fever break, no sequalae

41

mononucleosis in CMV infection is ___ antibody negative

antibody negative

42

cytomegalovirus infected cells show

owl eye, inclusion body

43

Ebstein Barr virus characteristics

dsDNA, nucleocapsid, tegument and envelope with glycoproteins, 3 stage gene expression

44

EBV lymphoma, B cell lymphoma of jaw and face, children 5-10, IgG promoter myc proto-oncogene, Associated with chromosomal translocation

Burkitt's lymphoma

45

Roseolovirus (HHV-6) latency in

T-lymphocytes

46

diagnosis CMV

IgM testing variable, IgG avidity increases with time to define primary infection and recent vs past. Viral DNA, culture and immunofluorescence

47

CMB latent infection in

CD34+ hematopoeitic progenitor cells, monocytes