VIral infections in transplant Flashcards Preview

Immune Micro 3 > VIral infections in transplant > Flashcards

Flashcards in VIral infections in transplant Deck (20):
1

common pre-engraftment infection, fever, diffuse rashi, can only diagnose via PCR of blood

herpes virus 6 HHV6

2

varicella infection window in transplant

beyond day 100

3

BK polyomavirus persists in (cell types)

most lkely promixal renal tubular cells

also lymphocytes and others

4

polymaviru small T antigen role

alter activity of cellular protein phosphatase

5

J domain of LT antigen role

DNA replication

6

CMV infection window in transplant

typically post engraftment

7

polymavirus tropism defined by

host cell surface gangliosides

7

JC polyomavirus persists in (cell types)

kidney, lymphocytes, bone marrow

7

Varicella infection secondary to reactivation commonly comorbid with

herpes zoster or primary chicken pox

8

only polyomavirus classified as causative agent of human malignancy

Merkel cell polyomavirus

9

polymavirus LXCXE role

binds and disrupts tumor suppressor proteins RB, p130, p107  > promotes cell proliferation

10

role of miRNA in polymavirus genome

shuts off early genes

12

early hemorrhagic cystitis associated with

 

late onset hemmorrhagic cystitis after day 15 from

early = cyclophosphamide primary to transplant

 

late due to DK JC virus, or adenovidurs

14

disease BK polyomavirus BKPyV

nephropathy in renal transpplant

BMT-hameorrhagic cystitis

induces tumors when inoculated into experimental animals

15

Adenovirus infection symptoms in transplant

URI

Diarrhea,

Conjunctivitis,

Cystitis,

Rash

hepatitis

neurologic disease

16

virology polymavirus

non-enveloped

circular dsDNA

17

polymavirus helicase role

binds and disrupts tumor suppresso rprotein p53

18

window for hepres infection in transplant

whole period

19

receptor for JC polyomavirus JCPyV receptor in glial cell culture

5-HT2A serotonin receptor

20