Respiratory Viruses Flashcards Preview

Immune Micro 3 > Respiratory Viruses > Flashcards

Flashcards in Respiratory Viruses Deck (31):
1

Rinovirus genus

picornaviurs

2

antigenic shift

infrequently, at hemagglutinin alone or neuraminidase as well

2

symptoms of rhinovirus due to

inflammatory response bradykinin and histamine

2

parinfluenza virus (mumps virus)

paramyxovirus

3

SARS and MERS-CoV are caused by

coronaviruses

4

respiratory adenovirus injections can lead to

systemic infection, destructive productive infection or latent infections

5

parainfluenza virus, tends to be asymptomatic or mild

HPIV4

7

second most prevalent cause of common colds, URI,

Coronaviruses

7

measles virus enus

morbillivirus

7

HN protein (hemagglutinin attachment an neuramindadase) not present in

RSV

9

two emerging respiratory viruses with high mortality rates, jump from bats to people in Australia and Asia

Paramyoxvirade Hendra and Nipah viruses

10

hendra, nipa genus

henipavirus

12

Orthomyxovirus genus

Thogovirus

13

complications of influenza virus infection

primary viral pneumonia, 2nd bacteria pneumonia, myositis and cardiac involvement, neurologic syndrome (Guillain barre, encephalopahty, encephalitis)

13

most common cause of fatal acute respiratory tract infection in infants and youn children, reinfection occur throughout life, ubitquitous

Paramyoxviridae - respiratory syncytial virus

15

antigenic drift

minor changes in hemagglutinin or neuroamindidase or both, resulting from mutations

17

pathogenesis Resipratory syncytial virus (paramyoxvirdae)

syncintia with mutli-nucleated giant cell, giant cell death leads to accumulation in airways leading to pathology

17

severe disease in infants/elderly/immunnocompromsied, pumonary disease and COPD, by age 5, all children seropositive. Second most common cause of RTI after RSv

Human metapneumovirus hMPV

18

acute influenza infection in adults

rapid fever, malaise, myalgia, sore throat, nonproductive cough

19

non structural proteins in paramyoxovirus family modulate immune response in vivo

NS1 and NS2

20

Influenza pathogenesis

infects ciliarted epithielial cells in upper respiratory > cell damage due to virus activated CTL (viremia not a major role)

21

parainfluenza virus, tend to infect later in life and common cause of croup

HPIV1 and 2

23

similar to respiratory syncytial virus RSV, common cause of LRI including bronchitis in first year of life (a parainfluenza virus)

HPIV3

24

common cause of acute and lower RI in infants, young children, elderly and immunocompromised

Human parainfluenza viruses

25

family, hemmaglutinin and neuroimindase activity on single protein (virlal attachment and release)

Paramyovirus

26

paramyoxovirus genome

ss negative RNA

27

acute influenza infection in children

higher fever than adults, GI symptoms, ortitis media, myositis, more frequent croup

28

maternal infection protect infant protection in RSV? (paramyoxvirdae)

no

29

most important in limiting reinfection of rhinovirus

secretory IgA

30

disease mechanism respiratory syncytial virus (paramyoxviridae)

localized to resp tract, penumonia from cytopathologic spread of virus, narrows airways of infants, bronchiolitis mediated by host response

31

respiratrtory syncytial virus, metapneumovirus genus

penumovirus