Neurotropic viruses Flashcards Preview

Immune Micro 3 > Neurotropic viruses > Flashcards

Flashcards in Neurotropic viruses Deck (26):
1

varicella zoster pathogensis

replication in Tcells, epithelial, endothelial >> Latency in widespread ganglia >> viral gene products translated in neuron >> secondary viremia

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diagnosis herpes varicella zoster

acute pain, DNA PCR, detections of VZV antigens in lesions via immunofluorescence

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lytic life cycle alpha genes

immediate genes - manipulate cell cycle

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treatment herpes virus

nucleoside analog drugs - acyclovir (no HSV vaccines, only for varicella zoster)

2

Varicella zoster vaccine, characteristics

live, attenuated virus Oka Strain

3

hand herpes dermatitis

herpes whitlow

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lytic life cycle gamma genes

late genes, code for virion structural components

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Beta herpes viruses

Cytomegalovirus, Roseolovirus, HHV-7

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prevention neonatal herpes

drugs prior to birth to supress viral reactivation

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circular viral DNA is associated with host ____ and maintained as a ____

with host nucleosomes (via chromatin) and maintained as an episome

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gamma herpes viruses length ofreplication cycle, latency location, host range

slow replication cycle, latency in lymphocytes and myeloid cells. Limited host range

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dermatitis of athletes in contact sports

herpes galdiatorium

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beta herpes viruses length ofreplication cycle, latency location, host range

long replication cycle, latency in secretory glands, lymphoreticular system, kidney. Limited host range

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herpes-linked blindness

herpes keratitis and conjunctivitis

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incubation period varicella zoster

10-21 days

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alpha herpes viruses characteristic

short replication cycle, latency in sensory ganglia, broader host range

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gamma herpes viruses

Epstein Barr, Kaposi's Sarcoma virus

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herpes varciella zoster basic clinical disease

chicken pox primary infection, blisters, itching, fever, malaise. secondary infections (pneumonia, skin infection, CNS)

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site of latency HSV 1 and 2

HSV 1 - trigmeninal ganglion, HSV-2 splanchnic

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alpha herpes viruses

HSV, Varicella zoster virus

20

lytic life cycle beta genes

early genes - code DNA synthesis machinery

22

defining properties herpes viruses (3)

Encode enzymes involved in nucleotide metabolism, DNA synthesis, and protein kinase. AND Synthesis of DNA and capsid in nucleus, rest of virion in cytoplasm. AND 2 life cycles: lytic and latency

23

diagnosis herpes

vesicles at site of inoculation, clinical virology (HSV antigens, PCR) serology to determine infection status

24

spread herpes varicella zoster

skin to skin - aerosolized fro mlesions and respiratory tract

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herpes varicella zoster Hepes zoster clinical presentation

reactivation of VZV from sensory ganglia, prostherpetic neuralgia (severe pain without vesicualr lesion, last for moths without relief)

26

varicella zoster vaccine impact

reduces severity of primary infection, can still reactivate later in life but with mild symptoms.Immunization later in life limits zoster