Neurotropic viruses

Question 1

varicella zoster pathogensis

Answer 1

replication in Tcells, epithelial, endothelial >> Latency in widespread ganglia >> viral gene products translated in neuron >> secondary viremia

Question 1

diagnosis herpes varicella zoster

Answer 1

acute pain, DNA PCR, detections of VZV antigens in lesions via immunofluorescence

Question 2

lytic life cycle alpha genes

Answer 2

immediate genes - manipulate cell cycle

Question 2

treatment herpes virus

Answer 2

nucleoside analog drugs - acyclovir (no HSV vaccines, only for varicella zoster)

Question 2

Varicella zoster vaccine, characteristics

Answer 2

live, attenuated virus Oka Strain

Question 3

hand herpes dermatitis

Answer 3

herpes whitlow

Question 4

lytic life cycle gamma genes

Answer 4

late genes, code for virion structural components

Question 5

Beta herpes viruses

Answer 5

Cytomegalovirus, Roseolovirus, HHV-7

Question 5

prevention neonatal herpes

Answer 5

drugs prior to birth to supress viral reactivation

Question 6

circular viral DNA is associated with host ____ and maintained as a ____

Answer 6

with host nucleosomes (via chromatin) and maintained as an episome

Question 8

gamma herpes viruses length ofreplication cycle, latency location, host range

Answer 8

slow replication cycle, latency in lymphocytes and myeloid cells. Limited host range

Question 9

dermatitis of athletes in contact sports

Answer 9

herpes galdiatorium

Question 10

beta herpes viruses length ofreplication cycle, latency location, host range

Answer 10

long replication cycle, latency in secretory glands, lymphoreticular system, kidney. Limited host range

Question 11

herpes-linked blindness

Answer 11

herpes keratitis and conjunctivitis

Question 12

incubation period varicella zoster

Answer 12

10-21 days

Question 14

alpha herpes viruses characteristic

Answer 14

short replication cycle, latency in sensory ganglia, broader host range

Question 15

gamma herpes viruses

Answer 15

Epstein Barr, Kaposi’s Sarcoma virus

Question 16

herpes varciella zoster basic clinical disease

Answer 16

chicken pox primary infection, blisters, itching, fever, malaise. secondary infections (pneumonia, skin infection, CNS)

Question 17

site of latency HSV 1 and 2

Answer 17

HSV 1 - trigmeninal ganglion, HSV-2 splanchnic

Question 18

alpha herpes viruses

Answer 18

HSV, Varicella zoster virus

Question 20

lytic life cycle beta genes

Answer 20

early genes - code DNA synthesis machinery

Question 22

defining properties herpes viruses (3)

Answer 22

Encode enzymes involved in nucleotide metabolism, DNA synthesis, and protein kinase. AND Synthesis of DNA and capsid in nucleus, rest of virion in cytoplasm. AND 2 life cycles: lytic and latency

Question 23

diagnosis herpes

Answer 23

vesicles at site of inoculation, clinical virology (HSV antigens, PCR) serology to determine infection status

Question 24

spread herpes varicella zoster

Answer 24

skin to skin - aerosolized fro mlesions and respiratory tract

Question 25

herpes varicella zoster Hepes zoster clinical presentation

Answer 25

reactivation of VZV from sensory ganglia, prostherpetic neuralgia (severe pain without vesicualr lesion, last for moths without relief)

Question 26

varicella zoster vaccine impact

Answer 26

reduces severity of primary infection, can still reactivate later in life but with mild symptoms.Immunization later in life limits zoster