Oncogenesis Flashcards Preview

Immune Micro 3 > Oncogenesis > Flashcards

Flashcards in Oncogenesis Deck (14):
1

integration disrupts expression of ___ gene, (a transcriptional repressor) allowing increased levels of E6 and E7

E2

2

Papilomavirus genes E1 and E2 code

replication and transcription of vial DNA

3

Papilomavirus E5 codes

stimulates constitutive growth factor receptor signaling

3

when Cdk/cyclin had accumulated in G1, ____ becomes phosphorylated and inactivated, allowing progression to S phase

Rb

5

inappropriate entry into cell cycle can activate ____ inducing production of Cdk/cyclin inhibitors to stop cell cycle

p53

6

E6 Papilomavirus protein recruits ubiquitan ligase that targets __ for degradation, preventing it from blocking progression into S phase or inducing apoptosis

p53

7

Papilomavirus genes L1 and L2 code

capsid

7

high risk strains of HPV tend to show

enhanced E6 E7 activity

8

___ of Papilomavirus induces expression of telomerase

E6

9

Papilomavirus genes E6 and E7 code

neutralize major brakes that regulate cell cycle (p53 and Rb) uncoupling cell division from control

10

Papilomavirus genes E4 code

disrupts cytokeratines to facilitate virus egress from tissue

12

E7 protein of Papilomavirus binds ____ and targets it for proteosomal degradation

Rb

13

HPV causes cell replication in ___ while typically only stratum basale cells replicate

stratum spinosum

14

Papilomavirus life cycle tied to what host factor

differentiation state of keratinocytes