Immune System Pathology Flashcards Preview

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Flashcards in Immune System Pathology Deck (27):
1

AIDS

-acquired immunodeficiency syndrome
-causes progressive destruction of T cells and changes in B cells

2

AIDS Risk Factors

-high risk behavior
-Men who have sex with men

3

AIDS Transmission

-bodily fluids
-high risk behaviors
-drug injection
-blood/blood products

4

AIDS Related Complex

-spectrum of HIV infection through AIDS diagnosis+

5

AIDS Affects the

-T4 helper T cells (lymphocytes) and destroys/inactivates them

6

CD4 Marker

-receptors for the retrovirus, allowing infection to enter cell

7

AIDS Sx

-vary with stage and age
-slow, rapid or non-progressive
-arthralgia
-myalgia
-night sweats
-GI problems
-oral/genital ulcers

8

3 Stages of AIDS

-Asymptomatic/Latency
-Early Symptomatic
-Advanced Disease/Overt AIDS

9

Asymptomatic Stage or Latency Stage

-CD4 >500 cells/mm^3
-no S/Sx
-healthy and continues to work

10

Early Symptoms Stage

-CD4: 200-500 cells/MM^3
-generalized, non-specific Sx
-immunocompromised
-weight loss
-fatigue
-night sweats
-fevers
-Sx from opportunisit infections

11

Advanced Disease/Overt AIDS Stage

-CD4 Count

12

Acute infection Sx

-fever
-fatigue
-rash
-headache
-lymphadenopathy
-pharyngitis

13

AIDS Diagnosis

-CD4 count

14

Normal CD4 levels

-500-1000 cells/mm^3

15

Common Opportunistic Infections

-pneumocystis carinii
-candida albicans fungus
-cytomegalovirus
-mycobacterium avium-intracellular complex
-mycobacterium tuberculosis

16

Cancers/Malignancies of AIDS

-kaposi's sarcoma
-wasting syndrome
-metabolic disorders (lipodystrophy, mitochondrial disorders)

17

Kaposi's Sarcoma

-purplish grape-like lesions on skin, GI tract and other organs

18

Wasting Syndrome

-weight loss of 10% of body weight
-diarrhea
-chronic weakness
-fever

19

Lipodystrophy

-selective loss of body fat
-people develop insulin resistance, diabetes, high triglyceride level, fatty liver

20

Diagnostic tests for AIDS

-ELISA (enzyme linked immunosorbent assay

-determine presence of antibodies to HIV in blood or oral fluids

21

AIDS Treatment

-no cure

22

Management of Treatment

-focus on CD4 cell count
-anti-retroviral
-Palliative care

23

AIDS and PT

-infection control
-exercise good for immune system

24

Systemic Exertion Intolerance Types

-Chronic Fatigue Syndrome
-Chronic Fatigue and Immune Dysfunction Syndrome
-Chronie Epstein-Barr Virus
-Myalgic Encephalomyelitis
-Neuromyasthenia

25

Definition of Systemic Exertion Intolerance Disease

-new onset of unexplained or chronic fatigue unrelated to sleep, exercise or changes in activity with 4 or more of following:
--impairment of memory/concntration
--sore throat
--tender lymph nodes
--muscle pain
--multiple arthralgias w/o swelling
--headaches
--unrefreshing sleep
--post-exertional malaise >24 hours

26

Pathogenesis of Systemic Exertion Intolerance Disease

-dysregulation of interaction between the nervous system and the immune system

27

Management of Systemic Exertion Intolerance Disease

-treatment of Sx
-avoid irritants & certain foods
-exercise
-graded exercise with cognitive behavioral therapy
-bacteriophages