What type of bacteria express LPS?
What is the PRR for LPS?
Where do naive B cells reside in the lymph nodes?
Where do naive T cells reside in the lymph nodes?
Through what do naive lymphocytes enter the lymph nodes?
High endothelial venules
What is IgM specialised for?
First responder. Activates classical pathway of complement cascade.
What is IgA specialised for?
present in mucosa. Neutralises
What is IgD specialised for?
rarest. Expressed on B cells
What is IgG specialised for?
Most common. Neutralises and opsonises. Antibody dependent cell-mediated cytotoxicity (ADCC); flag for NK cells
What is IgE specialised for?
Elevated in parasitic infections and allergy. Degranulation.
CD4+ T cells are also known as what type of T cell?
Helper T cells
CD8+ T cells are also known as what type of T cell?
Cytotoxic T cells
How long after entering tissue until neutrophils die?
Define Type II hypersensitivity
IgM and IgG are generated against host antigens on cell surface or ECM. Igs then initiate complement or disrupt normal funciton.
Define Type III hypersensitivity
IgM and IgG are generated and form immune complexes that can't be cleared and thus lodge in capillaries or glomeruli
How are immune complexes usually removed?
By resident macrophages in the spleen
Define allo graft
Transfer organs between different members of the same species
Which cells are responsible for the tissue graft rejection response?
In transplantation, what will cause rejection of a tissue within minutes to hours?
Preformed anti-donor antibodies and complement
In transplantation, what will cause rejection of a tissue within days to weeks?
Primary activation of T cells
What are the 3 classes of drug used in tissue transplantation?
Anti-inflammatories (GCS) Calcineurin inhibitors (eg cyclosporin, tacrolimus) Anti-proliferative (azathioprine)
What is the most commonly transplanted organ in Australia?
Which prostaglandin is the biggest contributor to inflammation?