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Nick's MD1 > Immunology > Flashcards

Flashcards in Immunology Deck (23):
1

What type of bacteria express LPS?

Gram negative

2

What is the PRR for LPS?

TLR4

3

Where do naive B cells reside in the lymph nodes?

Cortex

4

Where do naive T cells reside in the lymph nodes?

Paracortex

5

Through what do naive lymphocytes enter the lymph nodes?

High endothelial venules

6

What is IgM specialised for?

First responder. Activates classical pathway of complement cascade.

7

What is IgA specialised for?

present in mucosa. Neutralises

8

What is IgD specialised for?

rarest. Expressed on B cells

9

What is IgG specialised for?

Most common. Neutralises and opsonises. Antibody dependent cell-mediated cytotoxicity (ADCC); flag for NK cells

10

What is IgE specialised for?

Elevated in parasitic infections and allergy. Degranulation.

11

CD4+ T cells are also known as what type of T cell?

Helper T cells

12

CD8+ T cells are also known as what type of T cell?

Cytotoxic T cells

13

How long after entering tissue until neutrophils die?

Within hours

14

Define Type II hypersensitivity

IgM and IgG are generated against host antigens on cell surface or ECM. Igs then initiate complement or disrupt normal funciton.

15

Define Type III hypersensitivity

IgM and IgG are generated and form immune complexes that can't be cleared and thus lodge in capillaries or glomeruli

16

How are immune complexes usually removed?

By resident macrophages in the spleen

17

Define allo graft

Transfer organs between different members of the same species

18

Which cells are responsible for the tissue graft rejection response?

T cells

19

In transplantation, what will cause rejection of a tissue within minutes to hours?

Preformed anti-donor antibodies and complement

20

In transplantation, what will cause rejection of a tissue within days to weeks?

Primary activation of T cells

21

What are the 3 classes of drug used in tissue transplantation?

Anti-inflammatories (GCS) Calcineurin inhibitors (eg cyclosporin, tacrolimus) Anti-proliferative (azathioprine)

22

What is the most commonly transplanted organ in Australia?

Kidney

23

Which prostaglandin is the biggest contributor to inflammation?

PGE2