Intro to Antibiotics II Flashcards Preview

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Flashcards in Intro to Antibiotics II Deck (47)
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31

anthrax tx

tetracyclines and glycylcyclines

32

Q fever tx

tetracyclines and glycylcyclines

33

macrolides mechanism

bacteriostatic
-reversibly binds 50S subunit

34

macrolides

clarithromycin
azithromycin

35

macrolide spectrum

aerobic gram positive cocci and bacilli

inactive against most gram negatives

36

azithromycin tx

respiratory tract infetion
-coverage of strep pneumonia, h. influenza and atypicals - mycoplasma, chlamydophilia, legionella

37

macrolide drug interaction

CYP3A4 inhibition

38

lincosamide mechanism

bind to 50S suppress protein synthesis

39

spectrum of lincosamides

pneumococci, s. pyogenes, viridans streptococci, MSSA, b. fragilis

40

lung abscess tx

clindamycin

lincosamide

41

clindamycin

lincosamide

42

anaerobic lung and pleural space infetcion

clindamycin

43

oxazolidinones mechanism

inhibit protein synthesis binding 50S subunit

prevent larger fmet-tRNA complex formation

44

oxazolidinones specdtrum

gram positive staph (MSSA, MRSA, VRSA), streptococcus, enterococci, gram positive anaerobic cocci, gram positive rods

45

linezolid

oxazolidinone

absorbed well orally

reserve for multi-drug resistant organisms**

46

hospital acquired pneumonia by MSSA and MRSA

linezolid

47

adverse of oxazolidones

myelosuppression
-anemia, leukopenia, thrombocytopeina

GI sx, HA, rash