Lecture 14: Electrophys Flashcards Preview

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Flashcards in Lecture 14: Electrophys Deck (14):
1

Ohm's Law

V = I x R

2

What is the best example of a drug that targets ion channels? What do they do to which channels?

Local anesthetics; block VG-Na+ channels

3

Describe two types of neuronal firing

Tonic (pacemaker), associated with HCN channles and burst firing, associated with greater NT release

4

What happens when an AP reaches a nerve terminal?

Activation of VG-Ca2+ channels

5

Why do muscle cells contract in response to all presynaptic APs? (2)

1) High probability of ACh release in response to each AP, and 2) the muscle endplate—through extensive folding—provides a large surface area of nicotinic ACh receptors

6

Patients with myasthenia gravis respond immediately to...

Cholinesterase inhibitor

7

What do the cardiac glycosides do?

Antagonists of the Na+/K+ pump and are used in the treatment of congestive heart failure since they increase the strength of muscle contraction

8

Describe first and second pain

The first wave is mediated by large, myelinated axons (Aδ fibers), the second by smaller, non-myelinated axons which conduct more slowly (C fibers)

9

T/F: In contrast to ionotropic receptors, most G protein-coupled receptors give rise to smaller and slower EPSPs or IPSPs

True

10

Post-tetanic potentiation

Postsynaptic response is greater after a prior tetanus

11

Paired-pulse facilitation

Postsynaptic response is greater to a stimulus that comes rapidly after a prior stimulus

12

Paired-pulse facilitation and post-tetanic potentiation are both due to...What causes supprssed postsynaptic responses?

Ca2+ buildup; vesicle depletion

13

LTP involves what type of stimulation and activation of which receptors, allowing what through? What next?

High frequency stimulation; NMDA, Ca2+, phosphorylation (via CaMKII) and surface migration of AMPA receptors

14

How is LTD different?

Low-grade stimulation does not activate CaMKII, but rather Calcineurin, a phosphatase which removes AMPS receptors from the surface

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