Lecture 2 - Epithelial Cells

Question 1

Do epithelial cells have blood supply?

Answer 1

No

Question 2

What Is the Basal Lamina?

Answer 2

Lamina Lucida

Lamina Densa

Question 3

What is the basement membrane?

Answer 3

Lamina Densa
Reticular Fibers
Includes Anchoring Fibril (Type VII Collagen)

Question 4

Type IV collagen is made by ______.

Answer 4

Epithelial Cells

Question 5

Type III and VII collagen are made by ______.

Answer 5

Connective Tissue Cells

Question 6

Tight Junction Protein and Function

Answer 6

1. Claudin

2. Helps seal the cell, preventing water loss as well as the passage of substances in between the cells

Question 7

Adherent Junction Protein

Answer 7

Cadherin (interacts in precence of Ca2+) + Catenin + acting-binding protein + actin fillament

Question 8

Adherent Junction Shape and function

Answer 8

Surrounds the Cell, stability, and help seal the tight junction

Question 9

Desmosome Protein

Answer 9

Cadherin + Desmoplakin/Plakoglobin + Intermediate filament

Question 10

Desmosome Shape and Function

Answer 10

Does not encircle, goes through the cell, anchors to intermediate filaments, provides stability to the cell

Question 11

Gap Junction Protein

Answer 11

Connexin

Forms hydrophilic pore

Question 12

Hemidesmosome Protein

Answer 12

Integrin

Question 13

Microvilli Structure

Answer 13

Microfilaments go up into microvilli to give support

- Made of actin + connecting fibers

Question 14

Stereocilia

Answer 14

Longer than microvilli

branched

Question 15

function of stereocilia

Answer 15

facilitate absorption

Question 16

Cilia shape

Answer 16

Longer/wider than microvili

Question 17

cilia function

Answer 17

movement

Question 18

glandular epithelia orgin

Answer 18

from epithelial layer during fetal development

Question 19

glandular epithelia function

Answer 19

secretion

Question 20

goblet cell formation

Answer 20

During fetal development, goblet cells differentiate from epithelial cells

Question 21

Goblet cell function

Answer 21

secrete mucous for intestine and respiratory tracts

Question 22

Goblet cells, single or multicellular gland?

Answer 22

single

Question 23

Endocrine vs Exocrine

Answer 23

Endocrine does not have ducts

Exocrine has ducts

Question 24

Formation of endo/exocrine glands

Answer 24

During fetal development there is a proliferation and differentiation of epithelial cells into ductal and secretory epithelial cells
Do not break BL/BM

Question 25

Different Types of Exocrine Gland Structural classifications (simple x4)

Answer 25

1. Tubular
2. Branched Tubular
3. Acinar
4. Branched Acinar

Question 26

Different Types of Exocrine Gland Structural classifications (compound x3)

Answer 26

1. Tubular
2. Acinar
3. Tubuloacinar

Question 27

Different Types of exocrine glands (x3)

Answer 27

Merocrine
Holocrine
Apocrine

Question 28

Merocrine Secretion

Answer 28

Most Exocrine Glands

Most proteins do not diffuse across the membrane –> use exocytosis

Question 29

Apocrine Secretion

Answer 29

Apical membrane w/ cytoplasm and lipid droplet pinches off

-can produce large quantities –> mammary gland

Question 30

Holocrine Gland

Answer 30

aka sebaceous glands
cells disintegrate and everything goes into ducts
-think “pimple”

Question 31

Synonym for tight junctions

Answer 31

Zonulae Occuldens

Question 32

Synonym for adherent junctions

Answer 32

Zonula Adherens

Question 33

Synonym for desmosome

Answer 33

Macula Adherens