Lecture 8- Cartilage Flashcards Preview

Histology > Lecture 8- Cartilage > Flashcards

Flashcards in Lecture 8- Cartilage Deck (16):
1

What is cartilage?

Connective tissue

2

What are the types of cartilage?

- Hyaline
- Fibrocartilage
- Elastic

3

Where is hyaline cartilage found?

Articular cartilage, most joints

4

Where is fibrocartilage found?

pubic symphisis, vertebrae

5

Where is elastic cartilage found?

ear

6

What is the outer layer of cartilage called?

Perichondrium

7

Does the EC matrix in the perichondrium look the same as the ECM in the hyaline cartilage?

No. The perichondrium is dense CT with type I collagen. The ECM of hyaline cartilage is type II collagen with lots of ground substance forming a gel.

8

Why does the EC matrix in hyaline cartilage appear more purple?

Aggrecan and GAG containing negatively charged sulfates are basophilic. These mix with the type II collagen making the matrix appear purple.

9

What does the negative charge of the Glycoaminoglycans have an affinity for?

Water, making the matrix a gel like substance

10

What is the function of the type II collagen and the ground substance in hyaline cartilage?

- tensile strength
- ground substance makes it resistant to pressure

11

What types of cells are in the perichondrium and hyaline cartilage?

- fibroblasts
- chondrocyte in lacuna

12

Where are the fibroblasts found near cartilage?

perichondrium

13

Where are the chondrocytes found?

EC matrix of the hyaline cartilage. Usually surrounded by lacuna. The cells shrink when fixed and can become artifacts.

14

It takes a long time for damaged cartilage to repair itself. Why?

Cartilage is avascular. The blood supply is in the dense irregular connective tissue of the perichondrium.

15

Where do new chondrocytes and matrix come from?

1) fibroblast cells of perichonrium
2) differentiate into chonroblast
3) appositional growth
4) can divide and lay down matrix
5) interstitial growth

16

What is the difference between hyaline, elastic, and fibrocartilage?

- Elastic cartilage contains type II collagen and elastic fibers.
- Fibrocartilage is halfway between dense CT and hyaline cartilage. Also has type I collagen.
- Hyaline cartilage is connective tissue made mostly of type II collagen.