Lecture 8- Cartilage Flashcards Preview

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Flashcards in Lecture 8- Cartilage Deck (16)
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1
Q
What is cartilage?
A
Connective tissue
2
Q
What are the types of cartilage?
A
- Hyaline
- Fibrocartilage
- Elastic
3
Q
Where is hyaline cartilage found?
A
Articular cartilage, most joints
4
Q
Where is fibrocartilage found?
A
pubic symphisis, vertebrae
5
Q
Where is elastic cartilage found?
A
ear
6
Q
What is the outer layer of cartilage called?
A
Perichondrium
7
Q
Does the EC matrix in the perichondrium look the same as the ECM in the hyaline cartilage?
A
No. The perichondrium is dense CT with type I collagen. The ECM of hyaline cartilage is type II collagen with lots of ground substance forming a gel.
8
Q
Why does the EC matrix in hyaline cartilage appear more purple?
A
Aggrecan and GAG containing negatively charged sulfates are basophilic. These mix with the type II collagen making the matrix appear purple.
9
Q
What does the negative charge of the Glycoaminoglycans have an affinity for?
A
Water, making the matrix a gel like substance
10
Q
What is the function of the type II collagen and the ground substance in hyaline cartilage?
A
- tensile strength
- ground substance makes it resistant to pressure
11
Q
What types of cells are in the perichondrium and hyaline cartilage?
A
- fibroblasts
- chondrocyte in lacuna
12
Q
Where are the fibroblasts found near cartilage?
A
perichondrium
13
Q
Where are the chondrocytes found?
A
EC matrix of the hyaline cartilage. Usually surrounded by lacuna. The cells shrink when fixed and can become artifacts.
14
Q
It takes a long time for damaged cartilage to repair itself. Why?
A
Cartilage is avascular. The blood supply is in the dense irregular connective tissue of the perichondrium.
15
Q
Where do new chondrocytes and matrix come from?
A
1) fibroblast cells of perichonrium
2) differentiate into chonroblast
3) appositional growth
4) can divide and lay down matrix
5) interstitial growth
16
Q
What is the difference between hyaline, elastic, and fibrocartilage?
A
- Elastic cartilage contains type II collagen and elastic fibers.
- Fibrocartilage is halfway between dense CT and hyaline cartilage. Also has type I collagen.
- Hyaline cartilage is connective tissue made mostly of type II collagen.