Lecture 3 - Connective Tissue Flashcards Preview

Histology > Lecture 3 - Connective Tissue > Flashcards

Flashcards in Lecture 3 - Connective Tissue Deck (47)
Loading flashcards...
1

Function of connective tissue (x3)

1. Structural Support
2. Nutrition
3. Defense

2

What makes up connective tissue?

Support Cells
Extracellular Matrix (Fibers/Ground substance)
Blood or lymph vessel

3

Main function of fibroblast?

make fibers

4

Where would you expect to see a lot of active fibroblasts?

Growing individuals
Wound Healing

5

3 Types of fiber in connective tissue

1. Collagen
2. Reticular
3. Elastic

6

Collagen formation

Fibroblast + Vitamin C = procollagen --> collagen --> fibril --> fiber

7

Type I collagen function

Tensile Strength

8

What contains lots of type I collagen?

Skin, ligaments, tendons

9

Where is type IV collagen found?

Basal Lamina --> lamina densa

10

What attaches the cell to type IV collagen?

Laminin

11

Where can you find type VII collagen?

BM --> anchoring fibril

12

Where do you find type III collagen?

Reticular Lamina w/ in BM
Fibers are in spleen, lymph nodes, liver, endocrine glands

13

What is the main function of fibroblasts?

Make fibers

14

Where do fibers and ground substance come from?

Extracellular Matrix

15

What types of cells are found in connective tissue? (x8)

1. Adipocytes
2. Chondrocytes
3. Osteocytes
4. Fibroblasts
5. Leukocytes
6. Macrophages
7. Mast Cells
8. Plasma Cells

16

Where are adipocytes found?

CT of many organs

17

Where are chondrocytes found?

Cartilage

18

Where are osteocytes found?

Bone

19

What is the most common cell in CT

Fibroblasts

20

In general, what is the roll of mast cells?

Release mediators that contribute to the allergic response

21

In general, what are macrophages involved with?

Phagocytosis

22

Shape of plasma cells?

Nucleolus in the middle, spokes around the side

23

Why does cytoplasm stain purple?

Active cells produce protein (pink, acidophilic) and RNA (RER, blue, basophilic). When these colors mix, they produce purple.

24

What is the function of plasma cells?

Produce antibodies to an antigen that will trigger an immune response.

25

What is the most common type of collagen?

Type I

26

What is the process of forming a collagen fiber?

1. Collagen fiber + Vitamin C
2. Procollagen plus processing
3. Fibril formation which is striped
4. Bundle to form fiber

27

Where is Type I collagen most commonly found?

Ligaments, Skin, and Tendons

28

What is the major function of Type I collagen?

Tensile Strength

29

Where is Type IV Collagen found?

Basal Lamina

30

What attaches to type IV collagen?

Laminin which connects to the transmembrane protein integrin. Forms the hemidesmosome