Flashcards in Lecture 3 - Connective Tissue Deck (47)
Function of connective tissue (x3)
1. Structural Support
What makes up connective tissue?
Extracellular Matrix (Fibers/Ground substance)
Blood or lymph vessel
Main function of fibroblast?
Where would you expect to see a lot of active fibroblasts?
3 Types of fiber in connective tissue
Fibroblast + Vitamin C = procollagen --> collagen --> fibril --> fiber
Type I collagen function
What contains lots of type I collagen?
Skin, ligaments, tendons
Where is type IV collagen found?
Basal Lamina --> lamina densa
What attaches the cell to type IV collagen?
Where can you find type VII collagen?
BM --> anchoring fibril
Where do you find type III collagen?
Reticular Lamina w/ in BM
Fibers are in spleen, lymph nodes, liver, endocrine glands
What is the main function of fibroblasts?
Where do fibers and ground substance come from?
What types of cells are found in connective tissue? (x8)
7. Mast Cells
8. Plasma Cells
Where are adipocytes found?
CT of many organs
Where are chondrocytes found?
Where are osteocytes found?
What is the most common cell in CT
In general, what is the roll of mast cells?
Release mediators that contribute to the allergic response
In general, what are macrophages involved with?
Shape of plasma cells?
Nucleolus in the middle, spokes around the side
Why does cytoplasm stain purple?
Active cells produce protein (pink, acidophilic) and RNA (RER, blue, basophilic). When these colors mix, they produce purple.
What is the function of plasma cells?
Produce antibodies to an antigen that will trigger an immune response.
What is the most common type of collagen?
What is the process of forming a collagen fiber?
1. Collagen fiber + Vitamin C
2. Procollagen plus processing
3. Fibril formation which is striped
4. Bundle to form fiber
Where is Type I collagen most commonly found?
Ligaments, Skin, and Tendons
What is the major function of Type I collagen?
Where is Type IV Collagen found?