Lecture 20 - Immunity (inborn) & 21 Flashcards Preview

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Flashcards in Lecture 20 - Immunity (inborn) & 21 Deck (47)
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1

enzyme that Breaks down peptidoglycan

lysozyme

2

enzyme that is an Iron-chelator

lactoferrin

3

enzyme that Produces superoxide radicals

lactoperoxidase

4

what causes the unusual conformation in antimicrobial peptides?

cross-linking and excess proline

5

what are the two types of monocytes?

dendritic cells and macrophages

6

what are the two types of granulocytes?

neutrophils & mast cells

7

What are the two types of lymphocytes?

T-cell and B-cell

8

these are Characterized by stainable granules

neutrophils

9

these are Active phagocytes that do not enter tissues

neutrophils

10

these cells are Most often associated with allergic response

mast cells

11

tissue associated cells that are active in phagocytosis

macrophages

12

phagocytic cells that are more closely associated with presenting antigens to leukocytes

dendritic cells

13

what is the first response to infection?

inflammation

14

A group of approximately 30 soluble & membrane-bound proteins that recognizes immune complexes or cell surfaces of bacteria

Complement

15

which complement pathway requires an antibody?

classical pathway

16

marking/targeting of bacteria for destruction

opsonization

17

C3a is a mediator of _______

inflammation

18

C3b is a mediator of ________

opsonization

19

how do macrophages recognize microbes when they lack antibodies?

pattern recognition receptors

20

conserved recognition motifs are called

pathogen-associated molecular patterns (PAMPs)

21

what are the two types of bacterial killing in the phagolysosome?

oxidative and non-oxidative killing

22

recognizes complex of viral peptide with MHC I and kills infected cell

Cytotoxic T Cell

23

recognizes complex of bacterial peptide with MHC II and activates macrophage

TH1 cell

24

recognizes complex of antigenic peptide with MHC II and activates B cell

Helper T cell

25

Activates killing response in phagocytic cells

TH1 cells

26

Effective at killing intracellular pathogens that are phagosome-bound

TH1 cells

27

Stimulates innate response

TH1 cells

28

Activates plasma cell differentiation in response antibody-bound antigen

TH2 cells

29

Induces production of antibody

TH2 cells

30

Stimulates acquired response

TH2 cells

31

are soluble proteins made by B cells in response to exposure to nonself antigens

antibodies

32

what is another name for antibodies?

immunoglobulins

33

__________ consist of a heavy and light chain held together by disulfide linkages

Antibodies

34

what are the 4 sources of antibody diversity

1) Multiple coding seqncing segmts encoded in genome
2) Coding segments can be differentially combined
3) Variable spacing & recombination can add or delete nucleotides
4) Somatic hypermutation

35

which antibody isotope is Found largely on mucosal surfaces

IgA

36

which antibody isotope is an Effective neutralizing antibody

IgA

37

which antibody isotope is Found on immature B-cells

IgD

38

which antibody isotope is Ineffective at most functions

IgD

39

which antibody isotope Binds antigens and stimulates release of histamines from mast cells

IgE

40

which antibody isotope is Effective against parasitic worms

IgE

41

The central antibody of antibody-based immunity

IgG

42

Strong activator of opsonization and complement

IgG

43

Principle isotype in blood and extracellular fluid

IgG

44

First isotype expressed in acquired response

IgM

45

Can form pentamers to effectively bind large, multi-valent antigens

IgM

46

isotope that Cannot leave bloodstream

IgM

47

isotope Responsible for A/B blood typing

IgM