Lecture 20 - Immunity (inborn) & 21

Question 1

enzyme that Breaks down peptidoglycan

Answer 1

lysozyme

Question 2

enzyme that is an Iron-chelator

Answer 2

lactoferrin

Question 3

enzyme that Produces superoxide radicals

Answer 3

lactoperoxidase

Question 4

what causes the unusual conformation in antimicrobial peptides?

Answer 4

cross-linking and excess proline

Question 5

what are the two types of monocytes?

Answer 5

dendritic cells and macrophages

Question 6

what are the two types of granulocytes?

Answer 6

neutrophils & mast cells

Question 7

What are the two types of lymphocytes?

Answer 7

T-cell and B-cell

Question 8

these are Characterized by stainable granules

Answer 8

neutrophils

Question 9

these are Active phagocytes that do not enter tissues

Answer 9

neutrophils

Question 10

these cells are Most often associated with allergic response

Answer 10

mast cells

Question 11

tissue associated cells that are active in phagocytosis

Answer 11

macrophages

Question 12

phagocytic cells that are more closely associated with presenting antigens to leukocytes

Answer 12

dendritic cells

Question 13

what is the first response to infection?

Answer 13

inflammation

Question 14

A group of approximately 30 soluble & membrane-bound proteins that recognizes immune complexes or cell surfaces of bacteria

Answer 14

Complement

Question 15

which complement pathway requires an antibody?

Answer 15

classical pathway

Question 16

marking/targeting of bacteria for destruction

Answer 16

opsonization

Question 17

C3a is a mediator of _______

Answer 17

inflammation

Question 18

C3b is a mediator of ________

Answer 18

opsonization

Question 19

how do macrophages recognize microbes when they lack antibodies?

Answer 19

pattern recognition receptors

Question 20

conserved recognition motifs are called

Answer 20

pathogen-associated molecular patterns (PAMPs)

Question 21

what are the two types of bacterial killing in the phagolysosome?

Answer 21

oxidative and non-oxidative killing

Question 22

recognizes complex of viral peptide with MHC I and kills infected cell

Answer 22

Cytotoxic T Cell

Question 23

recognizes complex of bacterial peptide with MHC II and activates macrophage

Answer 23

TH1 cell

Question 24

recognizes complex of antigenic peptide with MHC II and activates B cell

Answer 24

Helper T cell

Question 25

Activates killing response in phagocytic cells

Answer 25

TH1 cells

Question 26

Effective at killing intracellular pathogens that are phagosome-bound

Answer 26

TH1 cells

Question 27

Stimulates innate response

Answer 27

TH1 cells

Question 28

Activates plasma cell differentiation in response antibody-bound antigen

Answer 28

TH2 cells

Question 29

Induces production of antibody

Answer 29

TH2 cells

Question 30

Stimulates acquired response

Answer 30

TH2 cells

Question 31

are soluble proteins made by B cells in response to exposure to nonself antigens

Answer 31

antibodies

Question 32

what is another name for antibodies?

Answer 32

immunoglobulins

Question 33

__________ consist of a heavy and light chain held together by disulfide linkages

Answer 33

Antibodies

Question 34

what are the 4 sources of antibody diversity

Answer 34

1) Multiple coding seqncing segmts encoded in genome 2) Coding segments can be differentially combined 3) Variable spacing & recombination can add or delete nucleotides 4) Somatic hypermutation

Question 35

which antibody isotope is Found largely on mucosal surfaces

Answer 35

IgA

Question 36

which antibody isotope is an Effective neutralizing antibody

Answer 36

IgA

Question 37

which antibody isotope is Found on immature B-cells

Answer 37

IgD

Question 38

which antibody isotope is Ineffective at most functions

Answer 38

IgD

Question 39

which antibody isotope Binds antigens and stimulates release of histamines from mast cells

Answer 39

IgE

Question 40

which antibody isotope is Effective against parasitic worms

Answer 40

IgE

Question 41

The central antibody of antibody-based immunity

Answer 41

IgG

Question 42

Strong activator of opsonization and complement

Answer 42

IgG

Question 43

Principle isotype in blood and extracellular fluid

Answer 43

IgG

Question 44

First isotype expressed in acquired response

Answer 44

IgM

Question 45

Can form pentamers to effectively bind large, multi-valent antigens

Answer 45

IgM

Question 46

isotope that Cannot leave bloodstream

Answer 46

IgM

Question 47

isotope Responsible for A/B blood typing

Answer 47

IgM