Flashcards in Lecture 21 - Immunity (acquired) Deck (30)
what are required for activation of the adaptive immune response?
Cytokines produced by innate response
T cells can recognize antigen only when presented on self proteins called ____________
major histocompatibility complex (MHC) proteins
T-cell activation is restricted both by _______ and by ________
antigen and MHC
what Presents to the CD8 T-cells
MHC Class I
what Presents to CD4 T-cells
MHC Class 2
Recognize antigen presented by MHC I protein on an infected cell
T-cytotoxic cells (T-cells)
Activates killing response in phagocytic cells
Activates plasma cell differentiation in response antibody-bound antigen
Effective at killing intracellular pathogens that are phagosome-bound
Induces production of antibody
Stimulates innate response
Stimulates acquired response
are soluble proteins made by B cells in response to exposure to nonself antigens
antigens are primarily short _______
what are the 4 sources of antibody diversity?
1) multiple coding sequencing segments encoded in genome
2) coding segments that can be combined
3) Variable spacing and recombination can add or delete nucleotides
4) somatic hypermutation
this source of antibody diversity Occurs after antigen presentation to naïve B-cells
which antibody isotype is Found largely on mucosal surfaces
which antibody isotype is Found on immature B-cells
which antibody isotype Binds antigens and stimulates release of histamines from mast cells
which antibody isotype is Effective against parasitic worms
which antibody isotype is responsible for allergies?
which antibody isotype is The central antibody of antibody-based immunity
which antibody isotype is a Strong activator of opsonization and complement
Principle isotype in blood and extracellular fluid
which antibody isotype is responsible for clearing out pathogens in your body?
which antibody isotype is Produced before somatic hypermutation
First isotype expressed in acquired response
antibody isotope that Can form pentamers to effectively bind large, multi-valent antigens
which antibody isotope cannot leave the bloodstream?