Lecture 21 - Immunity (acquired) Flashcards Preview

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Flashcards in Lecture 21 - Immunity (acquired) Deck (30)
1

what are required for activation of the adaptive immune response?

Cytokines produced by innate response

2

T cells can recognize antigen only when presented on self proteins called ____________

major histocompatibility complex (MHC) proteins

3

T-cell activation is restricted both by _______ and by ________

antigen and MHC

4

what Presents to the CD8 T-cells

MHC Class I

5

what Presents to CD4 T-cells

MHC Class 2

6

Recognize antigen presented by MHC I protein on an infected cell

T-cytotoxic cells (T-cells)

7

Activates killing response in phagocytic cells

TH1

8

Activates plasma cell differentiation in response antibody-bound antigen

TH2

9

Effective at killing intracellular pathogens that are phagosome-bound

TH1

10

Induces production of antibody

TH2

11

Stimulates innate response

TH1

12

Stimulates acquired response

TH2

13

are soluble proteins made by B cells in response to exposure to nonself antigens

antibodies (immunoglobulins)

14

antigens are primarily short _______

peptides

15

what are the 4 sources of antibody diversity?

1) multiple coding sequencing segments encoded in genome
2) coding segments that can be combined
3) Variable spacing and recombination can add or delete nucleotides
4) somatic hypermutation

16

this source of antibody diversity Occurs after antigen presentation to naïve B-cells

somatic hypermutation

17

which antibody isotype is Found largely on mucosal surfaces

IgA

18

which antibody isotype is Found on immature B-cells

IgD

19

which antibody isotype Binds antigens and stimulates release of histamines from mast cells

IgE

20

which antibody isotype is Effective against parasitic worms

IgE

21

which antibody isotype is responsible for allergies?

IgE

22

which antibody isotype is The central antibody of antibody-based immunity

IgG

23

which antibody isotype is a Strong activator of opsonization and complement

IgG

24

Principle isotype in blood and extracellular fluid

IgG

25

which antibody isotype is responsible for clearing out pathogens in your body?

IgG

26

which antibody isotype is Produced before somatic hypermutation

IgM

27

First isotype expressed in acquired response

IgM

28

antibody isotope that Can form pentamers to effectively bind large, multi-valent antigens

IgM

29

which antibody isotope cannot leave the bloodstream?

IgM

30

which antibody isotope is responsible for A/B blood typing?

IgM