Leishmaniasis

Question 1

Types

Answer 1

1-Cutaneous leishmaniasis

Localized skin ulcers

Caused by species like L. tropica, L. major, L. mexicana
2. Mucocutaneous leishmaniasis

Destructive lesions of mucous membranes (nose, mouth, throat)

Mainly caused by L. braziliensis
3. Visceral leishmaniasis (kala-azar)

Systemic infection: fever, hepatosplenomegaly, pancytopenia, weight loss
Caused by L. donovani, L. infantum, or L. chagasi

Question 2

Mode of transmission

Answer 2

*bite of an infected female phlebotomine sandfly

*The sandfly injects promastigotes into the skin, which are then phagocytosed by macrophages and transform into amastigotes that multiply intracellularly

Question 3

التحشيشة

Answer 3

Leshimaniasis…
*L….حرف
١-L.donovani identification in aspirate of spleen,bone marrow,lns is the golden standard
٢-Leshmania ag in urine k39,k26
3-latex agglutination test
4-liposomal amphotrecin b
حرف M
Meglamine antimonate
حرف N
Na sitbogluconate
Amphotericin B

Question 4

Diagnosis

Answer 4

1-L.donovani identification in aspirate of spleen,bone marrow,lns is the golden standard.
2-Leshmania ag in urine k39,k26.
3-latex agglutination test.
4-PCR
5-ELISA

Question 5

Treatment

Answer 5

1-Pentavalent antimonates:
Na sitbogluconate
Meglamine antimonate.
2-Amphotrecin B
3-Liposomal amphotrecin B
4-Pentamidine