Memory Disorders Flashcards

1
Q

Does subject complaint predict memory performance?

A

Not necessarily, but may pre-date formal deficits in some cases of dementia

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2
Q

Define memory

A

Processes used to acquire, store, retain, and retrieve information

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3
Q

What often accompanies profound anterograde amnesia?

A

Retrograde amnesia; eg: post traumatic amnesia

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4
Q

What is short-term memory?

A

Immediate memory

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5
Q

What is working memory?

A

Manipulation of immediate memory

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6
Q

How can immediate memory be measured?

A

Digit span

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7
Q

What is long-term memory?

A

Storing info over mins, hrs, years for later retrieval

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8
Q

How can long-term memory be measured?

A

List learning retrieval

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9
Q

What type of memory does anterograde amnesia affect: short-term or long-term?

A

Long-term

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10
Q

What are the types of declarative memory?

A

Episodic

Semantic

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11
Q

What are the types of non-declarative memory?

A

Skills and habits

Classical conditioning

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12
Q

What is procedural memory?

A

Long-term, implicit memory

Skill acquisition

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13
Q

What type of memory often breaks down: declarative or non-declarative?

A

Declarative

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14
Q

What is episodic memory?

A

Autobiographical - events in personal context

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15
Q

What is semantic memory?

A

General facts not specified to individual

Not contextual

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16
Q

What is the structure of declarative memory?

A

Hippocampus
Entorhinal cortex
Perirhinal cortex

17
Q

What is the entorhinal cortex?

A

Gateway into hippocampus

18
Q

Where does disease progression affecting declarative memory often start?

A

Entorhinal cortex

19
Q

What does the perirhinal cortex do?

A

Linked to object knowledge and recognition

20
Q

What does the parahippocampal region do?

A

Involved in spatial memory

21
Q

What does damage to the parahippocampal region cause?

A

Getting lost

22
Q

What does damage to different parts of the hippocampus cause?

A

Slightly different presentations of memory loss

23
Q

What is the dentate gyrus on the hippocampus responsible for?

A

Pattern recognition

24
Q

What is CA1 in the hippocampus very susceptible to?

A

Hypoxic injury

25
What is the left hippocampus more lateralised to do?
Verbal memory - List learning - Paired associate learning - Story recall
26
What is the right hippocampus more lateralised to do?
Non-verbal memory - Visuo-spatial associations - Face recall
27
What are some causes of memory impairment?
Degenerative disorders Cerebrovascular disorders Paroxysmal/transient disorders Surgical resection
28
What are the episodic memory structures in the midline?
``` Anterior thalamus Basal forebrain Mesial temporal region Mammillary bodies Retrosplenial cortex ```
29
What is transient global amnesia?
Anterograde amnesia for
30
What precipitates transient global amnesia?
Several, including - Sexual intercourse - Immersion in cold water - Emotional stress
31
Is there a disruption to self-identity in transient global amnesia?
No
32
What is the underlying cause of transient global amnesia?
Unknown
33
What is the most common cause of dementia?
Alzheimer's disease
34
When does Alzheimer's disease usually start?
Over 65
35
What is mild cognitive impairment?
Subclinical | Transition phase between normal ageing and dementia
36
What are the clinical signs of mild cognitive impairment?
Self-reported memory complaint Objective memory impairment Unaffected general cognitive functioning Normal capacity to perform activities of daily living
37
What are early memory complaints in mild cognitive impairments?
Name-face association: "What's his name?" | Object-place association: "Where did I leave my glasses?"