METABOLIC PROFILE DRUGS - The Gonadal Hormones & Inhibitors Flashcards Preview

Pharmacology > METABOLIC PROFILE DRUGS - The Gonadal Hormones & Inhibitors > Flashcards

Flashcards in METABOLIC PROFILE DRUGS - The Gonadal Hormones & Inhibitors Deck (27):
1

The major natural estrogens produced by women are

- Estradiol (Estradiol-17β, E2)
- Estron (E1)
- Estriol (E3)

2

True or False. Estrogens are required for normal sexual maturation and growth of the female

TRUE

3

True or False. Estrogens decrease the rate of resorption of bone

TRUE

4

True or False. Estrogens enhance the coagulability of blood

TRUE

5

The major synthetic estrogens are

- Dienestrol
- Diethylstilbestrol
- Benzestrol

6

True or False about estrogens. Estradiol binds strongly to an α2-globulin and albumin with lower affinity

TRUE

7

True or False about estrogens. Estradiol is converted by liver and other tissues to estron and estriol and their 2-hydroxylated derivatives and conjugated metabolites and excreted in the bile

TRUE

8

True or False about estrogens. Estrone and estriol have lower affinity for the estrogen receptors than estradiol

TRUE

9

Indications of synthetic estrogens are

- Primary hypogonadism
- Postmenopausal hormonal therapy
- Hormonal contraception

10

Main complications of estrogens’ therapy include

- Postmenopausal uterine bleeding
- Breast tenderness
- Hyperpigmentation

11

Main contraindications of estrogens’ therapy include

- Estrogen-dependent neoplasmas such as carcinoma of the endometrium or carcinoma of the breast
- Undiagnosed genital bleeding
- Liver disease

12

Tamoxifen is

Antiestrogen

13

Progesterone is secreted by

Corpus luteum

14

The major natural progestin is

Progesterone

15

True or False about progestins. Progesterone is rapidly absorbed following administration by any route

TRUE

16

True or False about progestins. In the liver, progesterone is metabolized to pregnanediol and conjugated with glucuronic acid.

TRUE

17

True or False about progestins. Significant amounts of progestins and their metabolites are excreted in the urine

TRUE

18

True or False. The normal ovary produces small amount of androgens, including testosterone, androstenedione, and degydroepiandrosterone.

TRUE

19

Noncontraceptive clinical uses of progestins are

- Hormone replacement therapy
- Dysmenorrhea
- Endometriosis

20

True or False. Estrogens possess immunomodulator properties, but progestins do immunodepressant ones.

TRUE

21

Mifepristone (RU-486) is

Antiprogestin

22

True or False. Mifepristone (RU-486) is used as a contraceptive and abortifacient.

TRUE

23

Actions of mifepristone (RU-486) include

- Inhibition of ovulation during the follicular phase by blocking hypothalamic-pituitary progesterone receptors, which suppresses midcycle gonadotropin release
- During the luteal phase, inhibition of progesterone action on the uterus, which induces prostaglandin release from the endometrium
- Termination of pregnancy by facilitating luteolysis, menstruation, uterine motility, softening of the cervix, and
detachment of the embryo.

24

True or False about oral contraceptives. The “combination pill” contains both estrogen and progestin

TRUE

25

True or False about oral contraceptives. Ethinyl estradiol and mestranol are commonly used in oral contraceptives

TRUE

26

True or False about oral contraceptives. The “minipill” contains progestin alone

TRUE

27

True or False about oral contraceptives. The “triphasic pill” contains estrogen, progestin, and luteinizing hormine (LH)

FALSE

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