Neuropsychopharmacology Part 1: Antidepressants and Antipsychotics Flashcards Preview

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Flashcards in Neuropsychopharmacology Part 1: Antidepressants and Antipsychotics Deck (34)
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1

fluoxetine: what is it, side effect

-SSRI antidepressant
-has effects on drug metabolism

2

sertraline: what is it, advantage over fluoxetine

-SSRI antidepressant
-less effects on drug metabolism than fluoxetine

3

duloxetine: what is it, use other than major use

-SNRI antidepressant (blocks both serotonin and norepinephrine uptake)
-neuropathic pain

4

bupropion: what is it, mechanism, uses other than major use

-atypical antidepressant
-blocks norepinephrine and dopamine uptake
-nicotine withdrawal, seasonal affective disorder

5

mirtazapine: what is it, mechanism

-atypical antidepressant
-blocks presynaptic alpha2 receptors and heteroreceptors in the brain

6

SSRI antidepressants (2)

fluoxetine, setraline

7

tricyclic antidepressants (2)

amitriptyline, clomipramine

8

symptoms of SSRI discontinuation syndrome; which SSRIs is this more common for?

-dizziness, light-headedness, vertigo, anxiety, fatigue, headache, tremor, visual disturbances
-sertraline

9

SSRI with which SSRI discontinuation syndrome is least likely to occur

fluoxetine

10

amitriptyline: what is it, use other than major use

-tricyclic antidepressant
-chronic neuropathic pain

11

clomipramine: what is it, use

-tricyclic antidepressant
-OCD

12

phenelzine: what is it, mechanism

-irreversible MAO inhibitor antidepressant
-blocks oxidative deamination of naturally occurring biogenic amines (norepinephrine, dopamine, serotonin)

13

irreversible MAO inhibitor antidepressant

phenelzine

14

in what dopamine pathway in the brain do positive symptoms of schizophrenia occur?

mesolimbic tract

15

in what dopamine pathway in the brain do negative symptoms of schizophrenia occur?

mesocortical tract

16

typical antipsychotics (4)

chlorpromazine, thioridazine, fluphenazine, haloperidol

17

typical antipsychotics: mechanism

dopamine D2 antagonists

18

side effects of typical antipsychotics, both short term (5) and long-term (1)

short-term: sedation, extrapyramidal symptoms, orthostatic hypotension, weight gain, neuroleptic malignant syndrome
long-term: tardive dyskinesia

19

atypical antipsychotics: mechanism

dopamine and serotonin receptor antagonists

20

why atypical antipsychotics are better than typical antipsychotics

less extrapyramidal symptoms

21

haloperidol: what it is, mechanism, use

-typical antipsychotic
-dopamine DA2 antagonist
-improves positive symptoms of schizophrenia

22

clozapine: what it is, mechanism, use, side effects

-atypical antipsychotic
-dopamine and serotonin receptor antagonist
-affects both positive AND negative symptoms of schizophrenia
-side effects: serious agranulocytosis or blood dyscrasias, less extrapyramidal effects

23

olanzapine: what it is, mechanism

-atypical antipsychotic
-dopamine and serotonin receptor antagonist

24

risperidone: what it is, mechanism

-atypical antipsychotic
-dopamine and serotonin receptor antagonist

25

quetiapine: what it is, mechanism

-atypical antipsychotic
-dopamine and serotonin receptor antagonist

26

aripiprazole: what it is, mechanism, use

-atypical antipsychotic
-D2 partial agonist, serotonin receptor antagonist
-adjunct in treatment of depression

27

atypical antipsychotics (5)

CORQuA: clozapine, olanzapine, risperidone, quetiapine, aripiprazole

28

drugs used to treat OCD

SSRIs and clomipramine

29

SNRI antidepressant: name and mechanism

duloxetine; blocks both serotonin and norepinephrine uptake

30

antidepressant also used for neuropathic pain

duloxetine