Flashcards in Neuropsychopharmacology Part 1: Antidepressants and Antipsychotics Deck (34)
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1
fluoxetine: what is it, side effect
-SSRI antidepressant
-has effects on drug metabolism
2
sertraline: what is it, advantage over fluoxetine
-SSRI antidepressant
-less effects on drug metabolism than fluoxetine
3
duloxetine: what is it, use other than major use
-SNRI antidepressant (blocks both serotonin and norepinephrine uptake)
-neuropathic pain
4
bupropion: what is it, mechanism, uses other than major use
-atypical antidepressant
-blocks norepinephrine and dopamine uptake
-nicotine withdrawal, seasonal affective disorder
5
mirtazapine: what is it, mechanism
-atypical antidepressant
-blocks presynaptic alpha2 receptors and heteroreceptors in the brain
6
SSRI antidepressants (2)
fluoxetine, setraline
7
tricyclic antidepressants (2)
amitriptyline, clomipramine
8
symptoms of SSRI discontinuation syndrome; which SSRIs is this more common for?
-dizziness, light-headedness, vertigo, anxiety, fatigue, headache, tremor, visual disturbances
-sertraline
9
SSRI with which SSRI discontinuation syndrome is least likely to occur
fluoxetine
10
amitriptyline: what is it, use other than major use
-tricyclic antidepressant
-chronic neuropathic pain
11
clomipramine: what is it, use
-tricyclic antidepressant
-OCD
12
phenelzine: what is it, mechanism
-irreversible MAO inhibitor antidepressant
-blocks oxidative deamination of naturally occurring biogenic amines (norepinephrine, dopamine, serotonin)
13
irreversible MAO inhibitor antidepressant
phenelzine
14
in what dopamine pathway in the brain do positive symptoms of schizophrenia occur?
mesolimbic tract
15
in what dopamine pathway in the brain do negative symptoms of schizophrenia occur?
mesocortical tract
16
typical antipsychotics (4)
chlorpromazine, thioridazine, fluphenazine, haloperidol
17
typical antipsychotics: mechanism
dopamine D2 antagonists
18
side effects of typical antipsychotics, both short term (5) and long-term (1)
short-term: sedation, extrapyramidal symptoms, orthostatic hypotension, weight gain, neuroleptic malignant syndrome
long-term: tardive dyskinesia
19
atypical antipsychotics: mechanism
dopamine and serotonin receptor antagonists
20
why atypical antipsychotics are better than typical antipsychotics
less extrapyramidal symptoms
21
haloperidol: what it is, mechanism, use
-typical antipsychotic
-dopamine DA2 antagonist
-improves positive symptoms of schizophrenia
22
clozapine: what it is, mechanism, use, side effects
-atypical antipsychotic
-dopamine and serotonin receptor antagonist
-affects both positive AND negative symptoms of schizophrenia
-side effects: serious agranulocytosis or blood dyscrasias, less extrapyramidal effects
23
olanzapine: what it is, mechanism
-atypical antipsychotic
-dopamine and serotonin receptor antagonist
24
risperidone: what it is, mechanism
-atypical antipsychotic
-dopamine and serotonin receptor antagonist
25
quetiapine: what it is, mechanism
-atypical antipsychotic
-dopamine and serotonin receptor antagonist
26
aripiprazole: what it is, mechanism, use
-atypical antipsychotic
-D2 partial agonist, serotonin receptor antagonist
-adjunct in treatment of depression
27
atypical antipsychotics (5)
CORQuA: clozapine, olanzapine, risperidone, quetiapine, aripiprazole
28
drugs used to treat OCD
SSRIs and clomipramine
29
SNRI antidepressant: name and mechanism
duloxetine; blocks both serotonin and norepinephrine uptake
30
