Neuropsychopharmacology Part 1: Antidepressants and Antipsychotics

Question 1

fluoxetine: what is it, side effect

Answer 1

• SSRI antidepressant

- has effects on drug metabolism

Question 2

sertraline: what is it, advantage over fluoxetine

Answer 2

• SSRI antidepressant

- less effects on drug metabolism than fluoxetine

Question 3

duloxetine: what is it, use other than major use

Answer 3

• SNRI antidepressant (blocks both serotonin and norepinephrine uptake)
• neuropathic pain

Question 4

bupropion: what is it, mechanism, uses other than major use

Answer 4

• atypical antidepressant
• blocks norepinephrine and dopamine uptake
• nicotine withdrawal, seasonal affective disorder

Question 5

mirtazapine: what is it, mechanism

Answer 5

• atypical antidepressant

- blocks presynaptic alpha2 receptors and heteroreceptors in the brain

Question 6

SSRI antidepressants (2)

Answer 6

fluoxetine, setraline

Question 7

tricyclic antidepressants (2)

Answer 7

amitriptyline, clomipramine

Question 8

symptoms of SSRI discontinuation syndrome; which SSRIs is this more common for?

Answer 8

• dizziness, light-headedness, vertigo, anxiety, fatigue, headache, tremor, visual disturbances
• sertraline

Question 9

SSRI with which SSRI discontinuation syndrome is least likely to occur

Answer 9

fluoxetine

Question 10

amitriptyline: what is it, use other than major use

Answer 10

• tricyclic antidepressant

- chronic neuropathic pain

Question 11

clomipramine: what is it, use

Answer 11

• tricyclic antidepressant

- OCD

Question 12

phenelzine: what is it, mechanism

Answer 12

• irreversible MAO inhibitor antidepressant

- blocks oxidative deamination of naturally occurring biogenic amines (norepinephrine, dopamine, serotonin)

Question 13

irreversible MAO inhibitor antidepressant

Answer 13

phenelzine

Question 14

in what dopamine pathway in the brain do positive symptoms of schizophrenia occur?

Answer 14

mesolimbic tract

Question 15

in what dopamine pathway in the brain do negative symptoms of schizophrenia occur?

Answer 15

mesocortical tract

Question 16

typical antipsychotics (4)

Answer 16

chlorpromazine, thioridazine, fluphenazine, haloperidol

Question 17

typical antipsychotics: mechanism

Answer 17

dopamine D2 antagonists

Question 18

side effects of typical antipsychotics, both short term (5) and long-term (1)

Answer 18

short-term: sedation, extrapyramidal symptoms, orthostatic hypotension, weight gain, neuroleptic malignant syndrome
long-term: tardive dyskinesia

Question 19

atypical antipsychotics: mechanism

Answer 19

dopamine and serotonin receptor antagonists

Question 20

why atypical antipsychotics are better than typical antipsychotics

Answer 20

less extrapyramidal symptoms

Question 21

haloperidol: what it is, mechanism, use

Answer 21

• typical antipsychotic
• dopamine DA2 antagonist
• improves positive symptoms of schizophrenia

Question 22

clozapine: what it is, mechanism, use, side effects

Answer 22

• atypical antipsychotic
• dopamine and serotonin receptor antagonist
• affects both positive AND negative symptoms of schizophrenia
• side effects: serious agranulocytosis or blood dyscrasias, less extrapyramidal effects

Question 23

olanzapine: what it is, mechanism

Answer 23

• atypical antipsychotic

- dopamine and serotonin receptor antagonist

Question 24

risperidone: what it is, mechanism

Answer 24

• atypical antipsychotic

- dopamine and serotonin receptor antagonist

Question 25

quetiapine: what it is, mechanism

Answer 25

- atypical antipsychotic | - dopamine and serotonin receptor antagonist

Question 26

aripiprazole: what it is, mechanism, use

Answer 26

- atypical antipsychotic - D2 partial agonist, serotonin receptor antagonist - adjunct in treatment of depression

Question 27

atypical antipsychotics (5)

Answer 27

CORQuA: clozapine, olanzapine, risperidone, quetiapine, aripiprazole

Question 28

drugs used to treat OCD

Answer 28

SSRIs and clomipramine

Question 29

SNRI antidepressant: name and mechanism

Answer 29

duloxetine; blocks both serotonin and norepinephrine uptake

Question 30

antidepressant also used for neuropathic pain

Answer 30

duloxetine

Question 31

atypical antidepressants (2)

Answer 31

mirtazapine, bupropion

Question 32

chlorpromazine: what it is, mechanism, use

Answer 32

- typical antipsychotic - dopamine D2 antagonist - treat schizophrenia

Question 33

thioridazine: what it is, mechanism, use

Answer 33

- typical antipsychotic - dopamine D2 antagonist - treat schizophrenia

Question 34

fluphenazine: what it is, mechanism, use

Answer 34

- typical antipsychotic - dopamine D2 antagonist - treat schizophrenia