Opioids Flashcards Preview

Block 3 Pharm > Opioids > Flashcards

Flashcards in Opioids Deck (25)
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1

neurotransmitters in ascending pain pathways

glutamate and substance P

2

neurotransmitters in descending pathways

norepinephrine, serotonin, and enkephalin

3

endogenous ligands of mu receptors

enkephalins, beta-endorphin

4

drugs that are mu receptor agonists

Must Catch Mike McMahon Fall
morphine, codeine, methadone, meperidine, fentanyl, buprenorphine (partial)

5

drugs that are mu receptor antagonists

naloxone, naltrexone

6

kappa receptor endogenous ligand

dynorphins

7

kappa receptor drug ligand

nalbuphine

8

morphine: what it is, administration, bioavialability

-mu agonist
-injectable or oral
-extensive first pass effect when taken orally

9

codeine: what it is, comparison with morphine

-mu agonist
-not as efficacious as morphine

10

methadone: what it is, comparison with morphine, uses

-mu agonist
-longer duration of action than morphine and has better oral bioavailability
-used in treatment of opioid addiction and chronic pain

11

mepiridine: what it is, comparison with morphine, side effect

-mu agonist
-shorter duration of analgesia than morphine
-side effect: forms toxic metabolite that can accumulate

12

fentanyl: what it is, comparison with morphine, administration

-mu agonist
-100X as potent as morphine
-injectable, transdermal patches

13

mixed-action agonist/antagonists (2)

nalpbuphine, buprenorphine

14

nalbuphine: what it is, comparison with morphine

-mu antagonist and kappa agonist
-much lower abuse potential

15

buprenorphine: what it is, use

-partial mu agonist
-oral buprenorphine combined with naloxone is used to treat opioid addiction

16

mu antagonists (2)

naloxone, naltrexone

17

naloxone: what it is, uses

-mu antagonist
-opioid overdoses
-combined with buprenorphine to treat opioid addiction

18

naltrexone: what it is, uses

-mu antagonist
-used to treat alcoholism, opiate addiction

19

dextromethorphan: use

antitussive

20

significant tolerance develops to what effects of opioids?

emetic action, analgesic, respiratory, euphoria and endocrine effects

21

no tolerance develops to what effects of opioids?

constipation and miosis

22

drugs given to treat opioid addiction (3)

methadone, buprenorphine+naloxone, naltrexone

23

why is naloxone added to buprenorphine to treat opioid addiction?

this preparation is given orally because if given parenterally, naloxone would block the effect of buprenorphine due to its much higher bioavailability

24

treats opioid overdoses

naloxone

25

treats alcoholism

naltrexone