Intro to CNS Pharmacology Flashcards Preview

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Flashcards in Intro to CNS Pharmacology Deck (17)
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1

leak channels open during resting membrane potential

K+, Cl-

2

action potentials: sequence of events

-localized depolarization-->voltage-gated sodium channels open
-voltage-gated potassium channels also open but their opening is more gradual and their inactivation is slower

3

action potentials are ______ and ______ in amplitude

all-or-none, 100 mV

4

synaptic potentials (IPSP, EPSP) are ______ and ______ in amplitude

graded, few mV

5

ways two kinds of EPSPs can occur

-increased conductance EPSPs: open ligand-gated channels for sodium or calcium
-decreased conductance EPSPs: close potassium leak channel

6

way in which IPSP can occur

open ligand-gated channels for potassium or chloride

7

gating mechanism for action potential vs. synaptic potentials

APs: voltage
synaptic: ligand/chemical

8

norepinephrine is important for what and via what receptors?

arousal/wakefulness (alpha receptors), autonomic nervous system regulation (beta receptors)

9

rate-limiting step of norepinephrine synthesis

conversion of tyrosine to L-DOPA by tyrosine hydroxylase

10

co-factor for tyrosine hydroxylase

BH4 (tetrahydrobiopterine)

11

autoreceptor responsible for feed-forward regulation of norepinephrine release (increases release)

beta receptor

12

autoreceptor responsible for feedback regulation of norepinephrine release (decreases release)

alpha2 receptor

13

3 mechanisms of norepinephrine inactivation

1. diffusion
2. reuptake by presynaptic neuron
3. enzymatic inactivation (MAO and COMT)

14

compare the vesicles that hold norepinephrine vs. neurotensin

-norepinephrine: small
-neurotensin: large, dense core

15

norepinephrine vs. neurotensin: compare where they are packaged

-norepinephrine: filled at the terminal
-neurotensin: packaged at the Golgi

16

norepinephrine vs. neurotensin: compare inactivation and what this implies

no reuptake by transporters for neurotensin, which means peptides tend to last longer

17

what are the 3 unique aspects of peptide signaling compared to amine neurotransmitter signaling

less directed, can last longer, lower fidelity