Antiparasitic Drugs Flashcards Preview

Block 3 Pharm > Antiparasitic Drugs > Flashcards

Flashcards in Antiparasitic Drugs Deck (20)
Loading flashcards...
1

treats neurocysticercosis

albendazole

2

drug of choice for Schistosoma

praziquantel

3

kills taenia solium eggs

praziquantel

4

which malarial species stay in liver and liver schizonts?

P. vivax and P. ovale

5

chloroquine: what is it, mechanism, uses

-blood schizonticide
-inhibits heme polymerization, allowing heme to accumulate to toxic levels
-prophylaxis for all 4 malarial species
-eradicates P. malariae and P. falciparum, targets only blood schizonts of P. vivax and P. ovale

6

drugs that prevent and treat chloroquine-resistant P. falciparum?

blood schizonticides: mefloquine, atovaquone+proguanil, quinine, and doxycycline

7

treatment of chloroquine-resistant P. falciparum and P. vivax

mefloquine

8

atovaquone+proguanil: mechanism

inhibit pyrimidine synthesis

9

what are the advantages of quinine over chloroquine?

quinine treats severe acute attacks and also treats chloroquine-resistant P. falciparum

10

what are the side effects of quinine?

-cinchoism: headache, visual disturbances, dizziness, tinnitus
-cardiac effects similar to quinidine

11

treatment of multi-drug resistant P. falciparum

doxycycline

12

antimalarial that is is also antibacterial; mechanism

doxycycline, inhibits malarial protein synthesis

13

primaquine: use

-kills liver hypnozoites
-radical cure/terminal prophylaxis of P. vivax and P. ovale
-should be used in conjunction with blood schizonticide

14

what drug kills liver hypnozoites and which malarial strains does this pertain to?

primaquine; P. vivax and P. ovale

15

giardia lamblia, trichomonas vaginalis, entamoeba histolytica

metronidazole

16

drugs for Pneumosystic jiroveci (carinii)

TMP-SMX, clindamycin+primaquine, atovaquone, dapsone (anti-leprosy)

17

praziquantel: uses (3)

-drug of choice for Schistosoma (blood flukes)
-good activity for some cestodes (tapeworms)
-for taenia solium

18

prophylaxis for chloroquine-resistant P. falciparum

atovaquone + proguanil

19

albendazole: uses (2)

-cutaneous larval migrans
-treats neurocysticercosis

20

entamoeba histolytica

metronidazole