Flashcards in Antiparasitic Drugs Deck (20)
Loading flashcards...
1
treats neurocysticercosis
albendazole
2
drug of choice for Schistosoma
praziquantel
3
kills taenia solium eggs
praziquantel
4
which malarial species stay in liver and liver schizonts?
P. vivax and P. ovale
5
chloroquine: what is it, mechanism, uses
-blood schizonticide
-inhibits heme polymerization, allowing heme to accumulate to toxic levels
-prophylaxis for all 4 malarial species
-eradicates P. malariae and P. falciparum, targets only blood schizonts of P. vivax and P. ovale
6
drugs that prevent and treat chloroquine-resistant P. falciparum?
blood schizonticides: mefloquine, atovaquone+proguanil, quinine, and doxycycline
7
treatment of chloroquine-resistant P. falciparum and P. vivax
mefloquine
8
atovaquone+proguanil: mechanism
inhibit pyrimidine synthesis
9
what are the advantages of quinine over chloroquine?
quinine treats severe acute attacks and also treats chloroquine-resistant P. falciparum
10
what are the side effects of quinine?
-cinchoism: headache, visual disturbances, dizziness, tinnitus
-cardiac effects similar to quinidine
11
treatment of multi-drug resistant P. falciparum
doxycycline
12
antimalarial that is is also antibacterial; mechanism
doxycycline, inhibits malarial protein synthesis
13
primaquine: use
-kills liver hypnozoites
-radical cure/terminal prophylaxis of P. vivax and P. ovale
-should be used in conjunction with blood schizonticide
14
what drug kills liver hypnozoites and which malarial strains does this pertain to?
primaquine; P. vivax and P. ovale
15
giardia lamblia, trichomonas vaginalis, entamoeba histolytica
metronidazole
16
drugs for Pneumosystic jiroveci (carinii)
TMP-SMX, clindamycin+primaquine, atovaquone, dapsone (anti-leprosy)
17
praziquantel: uses (3)
-drug of choice for Schistosoma (blood flukes)
-good activity for some cestodes (tapeworms)
-for taenia solium
18
prophylaxis for chloroquine-resistant P. falciparum
atovaquone + proguanil
19
albendazole: uses (2)
-cutaneous larval migrans
-treats neurocysticercosis
20
