Flashcards in Antiparasitic Drugs Deck (20)
drug of choice for Schistosoma
kills taenia solium eggs
which malarial species stay in liver and liver schizonts?
P. vivax and P. ovale
chloroquine: what is it, mechanism, uses
-inhibits heme polymerization, allowing heme to accumulate to toxic levels
-prophylaxis for all 4 malarial species
-eradicates P. malariae and P. falciparum, targets only blood schizonts of P. vivax and P. ovale
drugs that prevent and treat chloroquine-resistant P. falciparum?
blood schizonticides: mefloquine, atovaquone+proguanil, quinine, and doxycycline
treatment of chloroquine-resistant P. falciparum and P. vivax
inhibit pyrimidine synthesis
what are the advantages of quinine over chloroquine?
quinine treats severe acute attacks and also treats chloroquine-resistant P. falciparum
what are the side effects of quinine?
-cinchoism: headache, visual disturbances, dizziness, tinnitus
-cardiac effects similar to quinidine
treatment of multi-drug resistant P. falciparum
antimalarial that is is also antibacterial; mechanism
doxycycline, inhibits malarial protein synthesis
-kills liver hypnozoites
-radical cure/terminal prophylaxis of P. vivax and P. ovale
-should be used in conjunction with blood schizonticide
what drug kills liver hypnozoites and which malarial strains does this pertain to?
primaquine; P. vivax and P. ovale
giardia lamblia, trichomonas vaginalis, entamoeba histolytica
drugs for Pneumosystic jiroveci (carinii)
TMP-SMX, clindamycin+primaquine, atovaquone, dapsone (anti-leprosy)
praziquantel: uses (3)
-drug of choice for Schistosoma (blood flukes)
-good activity for some cestodes (tapeworms)
-for taenia solium
prophylaxis for chloroquine-resistant P. falciparum
atovaquone + proguanil
albendazole: uses (2)
-cutaneous larval migrans