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Flashcards in NSAIDs Deck (14)
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1

What NSAID is used predominantly for pain?

Parecoxib

2

What is the usual action of prostaglandins?

Pro-inflammatory, pyretic, hyperalgesic, inhibit gastric acid, platelet aggregation, contract the uterus and increase renal blood flow

3

What is the action of aspirin?

Antipyretic, anti-inflammatory, analgesic,GI side-effects, anti-platelet effect, delays labour and can cause kidney problems

4

Which form of COX is elevated in joint inflammatory disorders?

COX-2

5

Which types of COX are present in the stomach?

COX-1 in the crypts to protect the mucosa, and small amounts of COX-2 in the superficial mucosa

6

What physiological molecule prevents platelet aggregation?

Prostacyclin produced by endothelial cells

7

What physiological molecule promotes platelet aggregation?

Thromboxane from platelets

8

Which type of COX enzyme is involved in nociceptive transmission?

COX-2

9

Where is COX-2 present in the kidney?

Macula densa, increases in numbers when there is salt deprivation

10

What are the complications of COX-1 inhibition?

Loss of gastric protection, ulcers and bleeding

11

What is the best-tolerated NSAID for those with cardiovascular problems?

Naproxen

12

How does aspirin work?

Rapid reversible binding followed by covalent binding (irreversible)

13

How does diclofenac work?

Rapid, lower-affinity, reversible binding followed by time-dependent higher affinity, slowly reversible binding of COX-1 and COX-2

14

How does ibuprofen work?

Rapid competitive binding of COX-1 and COX-2