Flashcards in Inflammatory Joint Conditions Deck (19)
What is the differential diagnosis for an inflammatory joint condition?
It may be autoimmune e.g. RA, connective tissue disorder or spondyloarthritis (likely polyarthralgia), may be crystal arthropathy (monoarthralgia) or infection (monoarthralgia)
If a condition is polyarthralgic with synovitis and has lasted longer than 6 weeks what is it likely to be?
Systemic rheumatic disease
If a condition is polyarthralgic with synovitis and has lasted less than 6 weeks what is it likely to be?
If a condition is polyarthralgic without synovitis and with tender points what is it likely to be?
If a condition is polyarthralgic without synovitis or tender points what is it likely to be?
Osteoarthritis, soft tissue disorder, hypothyroidism etc.
What is the prevalence of rheumatoid arthritis?
387,000 adults (0.81% of population)
What is the incidence of rheumatoid arthritis?
12,000 new cases per year
What is the peak onset for rheumatoid arthritis?
20-50 years of age.
How does gender affect the risk of developing rheumatoid arthritis?
Females are 3x more likely (3:1)
What knee complications can occur due to rheumatoid arthritis?
Valgus deformity of the knee and Baker's cyst
What ocular complications can occur due to rheumatoid arthritis?
- Keratoconjunctivitis sicca (dry eyes)
- Scleritis and episcleritis (a serious inflammatory disease that affects the white outer coating of the eye)
- Scleromalacia perforans (necrotizing anterior scleritis)
What neuromuscular complications can occur due to rheumatoid arthritis?
Muscles wasting and carpal tunnel syndrome (may occur in early disease)
What systemic complications can occur due to rheumatoid arthritis?
IHD, reduced life expectancy and accelerated osteoporosis
Name some examples of connective tissue diseases
Systemic lupus erythematosus, scleroderma, dermatomyositis
What is scleroderma?
Long-term autoimmune disease that results in hardening of the skin
What is dermatomyositis?
Rare connective tissue disease characterised by inflammation of the muscles and skin
What is ankylosing spondylitis?
This condition is associated with onset of back discomfort before the age of 40 and tends to have an insidious onset with a duration greater than 3 months that is associated with morning stiffness and improvement with exercise. It has a strong genetic link to HLA-B27.
What is reactive arthritis?
This is a seronegative asymmetric form of arthritis that occurs following urethritis, cervicitis or infectious diarrhoea. There Is a less strong association with HLA-B27 but individuals with this condition may go on to develop ankylosing spondylitis.