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Hugh's MD1 Neuro > Pain > Flashcards

Flashcards in Pain Deck (21):
1

What is the function of the descending pathway that acts at the dorsal horn?

Modulates pain

- can increase or decrease its sensation

2

Which type of nociception fibres are myelinated?

A-delta

2

What is fibromyalgia?

Pain state that can't be linked to any pathology

3

What is the difference between dysfunctional pain and neuropathic pain?

In neuropathic pain there is some damage to part of the NS involved in nociception while in the dysfunctional pain there is no obvious pathology

4

What is the nocebo effect?

A inoculous stimuli that causes pain because the subject is expecting it to be painful

6

Where are the cell bodies for the sensory nerves?

Dorsal root ganglia

6

Are all nociceptors the same?

No, different nociceptors are determined by their range of different TRPV1 receptors

7

What is secondary hyperalgesia?

Where increased pain sensation occurs around an area of original pain/wound

9

Which type of nociception fibres are unmyelinated?

C-fibres

10

What temperature will elicit the pain response?

>52C

<15C

11

Inflammation pain can lead to what changes to pain sensation?

Sensitisation to pain

Spontaneous pain

11

What is allodynia?

Painful response to non-noxious stimuli

12

Which laminae in the dorsal horn do C-fibres synapse with?

i and ii

14

Which type of pain fibres do glabrous skin lack? What are the implications?

Type II A fibres 

They don't have the fast response

14

What type of pain does stimulation of C-fibres cause?

Slow, throbbing pain

15

Which tract do pain fibres communicate with the CNS via?

The anterolateral tract

17

What type of receptors receive nociceptive stimuli?

TRPV1

18

What are the 4 step of pain sensation?

Transduction

Transmission

Perception

Modulation

19

Which laminae in the dorsal horn do A-delta fibres synapse with?

i and v

20

What reflex response to pain?

Withdrawal

21

Can you have a nociceptive reflex without feeling pain?

Yes