Pathogenesis of Dementia Flashcards Preview

Hugh's MD1 Neuro > Pathogenesis of Dementia > Flashcards

Flashcards in Pathogenesis of Dementia Deck (19):
1

What pathological process occurs in the substantia nigra in Parkinson's?

Accumulation of lewy bodies

2

How much of Alzheimer's is genetic?

90%

2

What are neurofibrillary tangles?

Accumulations of tau protein that are markers of the progression of AD

2

What cause synaptic chaos in AD?

Abeta peptide dispersing in the brain and planting in the membrane at synapses

3

How does neuronal tissue with BSE appear microscopically?

There are fluid filled vacuoles within the cytoplasm of cells

4

What is best target for a disease modifying drug in AD?

Abeta oligomer

5

Which part of the brain is most commonly effected in AD first?

The medial temporal lobe

6

Where is Kuru found predominantly?

Papua New Ginea

7

What is the causative agent in transmissible spongiform encephalopathies?

Aberrant protein

7

What is the proper name of mad cow's disease?

Bovine spongiform encephalitis

9

What is the name of the peptide at the centre of AD?

Abeta

11

What are some risk modifying factors for ADs?

Education

Smoking

Vascular disease

Diabetes

Head trauma

Antioxidants

- their relative effect is small though

12

Why can't beta sheets be cleared in Alzheimer's?

They are insoluble

13

What is a more important cause of deficit in ADs, amyloid plaques or Abeta peptide?

Abeta peptide

15

What drives that accumulation of neurofibrillary tangles?

Abeta peptide

16

In which disease is alpha-synuclein aggregation the pathological process occurring? 

Parkinson's

17

What determines the clinical presentation of AD early on?

The part of the brain that is affected

18

Why is there still concern about BSE?

The peak period of human to human transmission will be in 2020. This is due to it taking decades to develop

19

Creutzfeldt-Jakob disease is an example of what type of disease?

Transmissible spongiform encephalopathies