Pathoma- Amyloid Flashcards Preview

CVPR exam 2 > Pathoma- Amyloid > Flashcards

Flashcards in Pathoma- Amyloid Deck (74)
Loading flashcards...
1

What do thyroid tumor cells in an amyloid background indicate?

medullary carcinoma of the thyroid

2

This is systemic deposition of AL amyloid derived from the Ig light chain; assoc with plasma cell dyscrasias.

1a amyloidosis

2

What is amylin?

an amyloid that is a byproduct of insulin that can deposit in the islets of the pancreas

3

What is senile cardiac amyloidosis?

non-mutated serum transthyretin deposits in the heart present in 25% of individuals >80yo usually asymptomatic

4

What is 1a amyloidosis?

systemic deposition of AL amyloid derived from the Ig light chain; assoc with plasma cell dyscrasias

4

What is systemic deposition of AA amyloid derived from SAA called?

2a amyloidosis

4

What are non-mutated serum transthyretin deposits in the heart called?

senile cardiac amyloidosis

4

dx? mutated serum transthyretin deposits in the heart leads to restrictive cardiomyopathy 5% of African Americans are carriers

familial amyloid cardiomyopathy

4

Name the localized amyloidoses.

1. familial amyloid cardiomyopathy 2. senile cardiac amyloidosis 3. DM associated 4. Alzheimers 5. dialysis-associated amyloidosis 6. medullary carcinoma of the thyroid

5

What is dialysis-associated amyloidosis?

beta-2-microglobulin deposits in joints dialysis pts

5

What is medullary carcinoma of the thyroid?

a thyroid tumor derived from C cells, leading to overproduction of calcitonin and then amyloid deposition in the thyroid

6

Dx? beta-2-microglobulin deposits in joints

dialysis-associated amyloidosis

7

How does amyloid look under the microscope?

congo red staining with apple green birefringence

9

What is the usual configuration of amyloid-damaged tissue?

Beta-pleated sheets

10

How can amyloidosis occur in Alzheimers disease?

beta-amyloid precursor protein on chromosome 21 deposits into the brain as ABeta forms amyloid plaques

11

Systemic amyloidosis is divided into ____ and ____ types.

1a; 2a

11

What are non-mutated serum transthyretin deposits in the heart called?

senile cardiac amyloidosis

11

How can amyloidosis occur in DM?

type 2 DM: too much insulin = insulin byproduct produced (amylin) amylin deposits into islets of the pancreas

12

What are the features of Familial Mediterranean Fever?

dysfunction of the neutrophils causing activation w/o infection auto recessive inheritance in persons of Mediterranean origin fever; serosal surfaces inflamed; tongue enlargement, hepatosplenomegaly, malabsorption

12

How is amyloidosis definitively diagnosed?

a tissue biopsy (usu a fat pad- abdominal or rectal)

14

What is the usual configuration of amyloid-damaged tissue?

Beta-pleated sheets

14

Name the localized amyloidoses.

1. familial amyloid cardiomyopathy 2. senile cardiac amyloidosis 3. DM associated 4. Alzheimers 5. dialysis-associated amyloidosis

15

What is restrictive cardiomyopathy?

stiffened heart can't dilate as well or pump properly, leading to HF

16

How can amyloidosis occur in Alzheimers disease?

beta-amyloid precursor protein on chromosome 21 forms ABeta amyloid forms amyloid plaques in the brain

18

What is 2a amyloidosis?

systemic deposition of AA amyloid derived from SAA

19

Where does amyloid most commonly deposit? What does this cause?

the kidney; nephrotic syndrome

20

What is an amyloid?

a misfolded protein that deposits into the extracellular space

20

What is SAA?

an acute phase reactant increased in inflammation, malignancy, and Familial Mediterranean fever

20

What kind of amyloidosis category does senile cardiac amyloidosis fall into?

localized amyloidosis

21

What is familial amyloid cardiomyopathy?

mutated serum transthyretin deposits in the heart leads to restrictive cardiomyopathy 5% of African Americans are carriers