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Flashcards in Acute Coronary Syndrome Deck (30)
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1

What is the persistence of cTnI?

3-10 days

2

What is the persistence of myoglobin?

24 hours

3

What is the persistence of cTnT?

7-10 days

4

What does ACS stand for?

acute coronary syndrome

5

What is the time to peak elevation of cTnT?

12-48 hours

5

What is the onset of detection of LD-I?

10-12 hours

6

Unstable angina?

discomfort which is new in onset or is increased in duration, frequency or intensity with less exertion or at rest compared to previous episodes of discomfort

7

How is STEMI treated?

1. open the artery- give fibrinolytic if cath lab is >90 min away 2. reduce myocardial O2 demand w/ beta-blockers and nitrates (if stable)

8

What is STEMI?

Complete coronary vessel occlusion: ST elevation myocardial infarction (STEMI)

9

_____ is very sensitive and specific for myocardium.

Cardiac troponin

10

What is acute coronary syndrome (ACS)?

any array of clinical symptoms resulting from underlying acute myocardial ischemia

11

What is the persistence of LD-I?

7-10 days

11

How are NSTEMI or unstable angina treated?

halt the coagulation cascade (enoxaparin, heparins OR bival/thrombolytics) AND the platelet cascade (aspirin + P2Y12 inhibitor OR -ogrels OR GPIIb/IIIa inhibitor)

13

What is the onset of detection of cTnT?

4-6 hours

13

Partial coronary vessel occlusion, escalating symptoms without myocardial necrosis?

unstable angina

14

Stable angina?

present when there is increased demand for myocardial oxygen in a reproducible fashion

15

present when there is increased demand for myocardial oxygen in a reproducible fashion

stable angina

16

What is the onset of detection of myoglobin?

1-2 hours

18

What is the time to peak elevation of cTnI?

12 hours

19

What is the onset of detection of cTnI?

4-6 hours

20

What is the onset of detection of CK-MB isoforms?

4-6 hours

21

Dysfunctional endothelium + coagulation + platelet aggregation =

Coronary thrombosis

23

What is the persistence of CK-MB isoforms?

2-4 days

24

What is the time to peak elevation of LD-I?

48-72 hours

25

Causes of ACS?

Atherosclerotic plaque rupture with thrombus Coronary embolism Congenital anomalies Coronary trauma or aneurysm Severe coronary artery spasm (e.g. cocaine) Increased blood viscosity Spontaneous coronary dissection Markedly increased myocardial O2 demand

26

discomfort which is new in onset or is increased in duration, frequency or intensity with less exertion or at rest compared to previous episodes of discomfort

unstable angina

27

What is the time to peak elevation of CK-MB isoforms?

18 hours

28

What is NSTEMI?

Partial coronary vessel occlusion with myocardial necrosis: non ST elevation MI (NSTEMI)

29

any array of clinical symptoms resulting from underlying acute myocardial ischemia

acute coronary syndrome (ACS)

30

What is the time to peak elevation of myoglobin?

8-10 hours