Flashcards in Antithrombotic Agents Deck (38)
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1
Venous thrombi are composed mainly of _____ and _______ with relatively few ______.
fibrin; trapped red blood cells; platelets
2
______ are composed mainly of fibrin and trapped red blood cells with relatively few platelets.
Venous thrombi
3
Arterial thrombi are composed mainly of _____ held together by small amounts of _____.
platelet aggregates; fibrin
4
______ are composed mainly of platelet aggregates held together by small amounts of fibrin.
Arterial thrombi
5
How is UA/NSTEMI treated?
Aspirin
± clopidogrel or prasugrel or ticagrelor
± UFH or LMWH or fondaparinux
± GPIIb/IIIa inhibitor
6
How is an Acute MI (STEMI) treated?
Aspirin
+ clopidogrel or prasugrel or ticagrelor
+ UFH or LMWH or fondaparinux
± GPIIb/IIIa inhibitor
7
What medications are given before PCI?
Aspirin
+ clopidogrel or prasugrel or ticagrelor
+ UFH or LMWH or bivalirudin
± GPIIb/IIIa inhibitor
8
How is A-fib treated?
Warfarin or dabigatran or rivaroxaban or apixaban
9
What does the CHA2DS2-VASc acronym stand for?
Congestive HF-Hypertension-Age ≥ 75-
Diabetes-Stroke-Vascular disease-Age 65-74-Sex (female)
10
How does Warfarin work?
Inhibit synthesis of Vit K-dependent clotting factors II, VII, IX, and X
11
How does Heparin work?
Combines with antithrombin III (ATIII) to inactivate active clotting factors (IIa, IXa, Xa, XIa, XIIa)
12
How do LMWHs/Fondaparinux work?
they combine with antithrombin III (ATIII) to inactivate Xa
13
How do Hirudin, Dabigatran work?
they directly inactivate IIa (thrombin)
14
Which drug directly inactivates IIa (thrombin)?
Hirudin
Dabigatran
15
How does Rivaroxaban work?
Directly inactivates Xa
16
Which drug directly inactivates Xa?
Rivaroxaban
17
Which drug combines with antithrombin III (ATIII) to inactivate Xa?
LMWHs
Fondaparinux
18
Which drug combines with antithrombin III (ATIII) to inactivate active clotting factors (IIa, IXa, Xa, XIa, XIIa)?
heparin
19
Which drug inhibits synthesis of Vit K-dependent clotting factors II, VII, IX, and X?
warfarin
20
What test is used to monitor heparin therapy?
aPTT
21
What is a normal aPTT value?
26-33 sec
22
Prolonged clotting time in the aPTT indicates a defect in?
the intrinsic pathway
23
What test is used to monitor warfarin therapy?
PT
24
The aPTT test is used to monitor ____ therapy.
heparin
25
The PT test is used to monitor ____ therapy.
warfarin
26
What is a normal PT time?
12-14 sec (but now reported using INR)
27
What does ECT stand for?
Ecarin Clotting Time
28
What is Ecarin Clotting Time (ECT) used for?
to monitor anticoagulant therapy with direct thrombin (IIa) inhibitors (hirudin and dabigatran)
29
Which test is used to monitor anticoagulant therapy with direct thrombin (IIa) inhibitors (hirudin and dabigatran)?
Ecarin Clotting Time (ECT)
30
