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Flashcards in Antithrombotic Agents Deck (38)
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1

Venous thrombi are composed mainly of _____ and _______ with relatively few ______.

fibrin; trapped red blood cells; platelets

2

______ are composed mainly of fibrin and trapped red blood cells with relatively few platelets.

Venous thrombi

3

Arterial thrombi are composed mainly of _____ held together by small amounts of _____.

platelet aggregates; fibrin

4

______ are composed mainly of platelet aggregates held together by small amounts of fibrin.

Arterial thrombi

5

How is UA/NSTEMI treated?

Aspirin

± clopidogrel or prasugrel or ticagrelor

± UFH or LMWH or fondaparinux

± GPIIb/IIIa inhibitor

6

How is an Acute MI (STEMI) treated?

Aspirin

+ clopidogrel or prasugrel or ticagrelor

+ UFH or LMWH or fondaparinux

± GPIIb/IIIa inhibitor

7

What medications are given before PCI?

Aspirin

+ clopidogrel or prasugrel or ticagrelor

+ UFH or LMWH or bivalirudin

± GPIIb/IIIa inhibitor

8

How is A-fib treated?

Warfarin or dabigatran or rivaroxaban or apixaban

9

What does the CHA2DS2-VASc acronym stand for?

Congestive HF-Hypertension-Age ≥ 75-
Diabetes-Stroke-Vascular disease-Age 65-74-Sex (female)

10

How does Warfarin work?

Inhibit synthesis of Vit K-dependent clotting factors II, VII, IX, and X

11

How does Heparin work?

Combines with antithrombin III (ATIII) to inactivate active clotting factors (IIa, IXa, Xa, XIa, XIIa)

12

How do LMWHs/Fondaparinux work?

they combine with antithrombin III (ATIII) to inactivate Xa

13

How do Hirudin, Dabigatran work?

they directly inactivate IIa (thrombin)

14

Which drug directly inactivates IIa (thrombin)?

Hirudin

Dabigatran

15

How does Rivaroxaban work?

Directly inactivates Xa

16

Which drug directly inactivates Xa?

Rivaroxaban

17

Which drug combines with antithrombin III (ATIII) to inactivate Xa?

LMWHs

Fondaparinux

18

Which drug combines with antithrombin III (ATIII) to inactivate active clotting factors (IIa, IXa, Xa, XIa, XIIa)?

heparin

19

Which drug inhibits synthesis of Vit K-dependent clotting factors II, VII, IX, and X?

warfarin

20

What test is used to monitor heparin therapy?

aPTT

21

What is a normal aPTT value?

26-33 sec

22

Prolonged clotting time in the aPTT indicates a defect in?

the intrinsic pathway

23

What test is used to monitor warfarin therapy?

PT

24

The aPTT test is used to monitor ____ therapy.

heparin

25

The PT test is used to monitor ____ therapy.

warfarin

26

What is a normal PT time?

12-14 sec (but now reported using INR)

27

What does ECT stand for?

Ecarin Clotting Time

28

What is Ecarin Clotting Time (ECT) used for?

to monitor anticoagulant therapy with direct thrombin (IIa) inhibitors (hirudin and dabigatran)

29

Which test is used to monitor anticoagulant therapy with direct thrombin (IIa) inhibitors (hirudin and dabigatran)?

Ecarin Clotting Time (ECT)

30

Name 2 LMWHs.

Enoxapirin (Lovenox)

Dalteparin (Fragmin)