Antiplatelet Agents Flashcards Preview

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Flashcards in Antiplatelet Agents Deck (8)
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1

How does aspirin work?

it inhibits COX-1 synthesis of thromboxane in platelets

2

What drug inhibits COX-1 synthesis of thromboxane in platelets?

aspirin

3

How do Clopidogrel (Plavix), Prasugrel (Effient), and Ticagrelor (Brilinta) work?

they're ADP (purinergic-P2Y12) receptor antagonists that interfere with ADP-induced platelet aggregation.

4

These drugs are ADP (purinergic-P2Y12) receptor antagonists that interfere with ADP-induced platelet aggregation.

Clopidogrel (Plavix), Prasugrel (Effient), and Ticagrelor (Brilinta)

5

How does Dipyridamole (Persantine) work?

Blocks phosphodiesterase breakdown of cAMP, elevating cAMP levels and potentiating prostacyclin’s anti-aggregatory action

6

This drug blocks phosphodiesterase breakdown of cAMP, elevating cAMP levels and potentiating prostacyclin’s anti-aggregatory action.

Dipyridamole (Persantine)

7

How do Abciximab (Reopro), Eptifibatide (Integrelin), and Tirofiban (Aggrastat) work?

Blocks IIb/IIIa receptors on platelet thus preventing integrin and fibrinogen binding that facilitates aggregation (platelet-platelet binding).

8

These drugs block IIb/IIIa receptors on platelet, thus preventing integrin and fibrinogen binding that facilitates aggregation (platelet-platelet binding).

Abciximab (Reopro), Eptifibatide (Integrelin), and Tirofiban (Aggrastat)