Vasodilators in Angina Flashcards Preview

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Flashcards in Vasodilators in Angina Deck (29)
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1

HR and contractility are decreased with ___ and ____.

Beta-blockers and some Ca++ channel blockers

2

Flow to ischemic subendocardial tissue is improved with _____, _____, and _____.

nitrates, Beta-blockers, and Ca++ channel blockers

3

Coronary blood flow is increased with _____ and _____.

nitrates; Ca++ channel blockers

4

Preload is decreased by _____.

nitrates

5

Afterload is decreased by _____.

Ca++ channel blockers

6

What does CCB stand for?

Ca++ channel blockers

7

How do you treat Variant/Prinzmetal Angina?

vasodilators: nitrates and Ca++ channel blockers

8

Unstable angina is ACUTELY treated with?

clot: aspirin, heparin, GPIIB-IIIA inhibitors, PTCA/CABG,
fibrinolytics

arrhythmia: Beta-blockers

pain: NTG, morphine

9

What is the post-MI treatment?

ACEIs, statins, blockers, aspirin, clopidrogel (if post-stent).

10

How do nitrates work?

converted to nitric oxide (NO) at or near the plasma membrane of vascular smooth muscle cells --> increasing cGMP--> relaxation of smooth muscle

11

What is the best route for nitrate admin?

sublingual

12

What is the t1/2 of a nitrate?

2-8 min

13

What are some important SEs for nitrates?

low BP, headache, tolerance

14

Name 3 Ca++ channel blockers.

1. Verapamil (Calan)

2. Diltiazem (Cardizem)

3. Nifedipine (Procardia)

15

What are these drugs?

1. Verapamil (Calan)

2. Diltiazem (Cardizem)

3. Nifedipine (Procardia)

Ca++ channel blockers

16

How do Ca++ channel blockers work?

Block of L-type Ca++ channels in cardiac and smooth muscle --> smooth muscle relaxation

17

Which Ca++ channel blocker should NOT be used?

Nifedipine (Procardia)

18

When are Ca++ channel blockers used?

1. angina

2. arrhythmias

3. HTN

19

What are the important SEs of Ca++ channel blockers?

1. cardiac depression

2. flushing, edema, dizziness, nausea, constipation

20

What is Ranolazine (Ranexa)?

an inhibitor of the late Na+ current

21

When is Ranolazine (Ranexa) used?

as an add on for angina or as a sub. for beta-blockers

22

Use this as an add on for angina or as a sub. for beta-blockers.

Ranolazine (Ranexa)

23

What are some important SEs for Ranolazine (Ranexa)?

1. QT prolongation

2. other CV effects (less common)

24

When is a beta-blocker used for angina?

in stable angina with a concurrent arrhythmia or HTN

25

Which beta-blocker is used in angina?

Metoprolol (Lopressor), atenolol

26

Use this drug in a pt with stable angina with a concurrent arrhythmia or HTN.

Metoprolol (Lopressor) or atenolol-- both beta blockers

27

What is Metoprolol (Lopressor)?

a beta blocker

28

When is Metoprolol (Lopressor) contraindicated?

in asthmatics or with peripheral vascular disorders

29

Name 2 nitrates.

1. nitroglycerin (NTG)

2. oral nitrates