Thrombolytic (Fibrinolytic) Agents Flashcards Preview

CVPR exam 2 > Thrombolytic (Fibrinolytic) Agents > Flashcards

Flashcards in Thrombolytic (Fibrinolytic) Agents Deck (10)
Loading flashcards...
1

The central process of _____ is the conversion of inactive plasminogen to the active proteolytic enzyme plasmin.

fibrinolysis

2

The central process of fibrinolysis is the conversion of inactive ______ to the active proteolytic enzyme _____.

plasminogen; plasmin

3

All fibrinolytic drugs produce rapid lysis of thrombi by increasing formation of ______ from ______.

plasmin; plasminogen

4

How does Streptokinase (Streptase) work?

converts uncomplexed plasminogen to active plasmin- Generally results in systemic activation of plasmin

5

This drug converts uncomplexed plasminogen to active plasmin- Generally results in systemic activation of plasmin.

Streptokinase (Streptase)

6

How does Tissue Plasminogen Activator (tPA): Alteplase (Activase) work?

binds to fibrin and selectively activates bound plasminogen

7

This drug binds to fibrin and selectively activates bound plasminogen.

Tissue Plasminogen Activator (tPA): Alteplase (Activase)

8

What are Reteplase (Retevase) and Tenecteplase (TNKase)?

fibrinolytics that convert plasminogen into plasmin- they have a prolonged duration of action

9

Which fibrinolytics have a prolonged duration of action?

Reteplase (Retevase) and Tenecteplase (TNKase)

10

When are fibrinolytic agents used?

1. acute MI

2. DVT

3. multiple PE